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Cytokines and Chemokines Are Detectable in Swivel-Derived Exhaled Breath Condensate (SEBC): A Pilot Study in Mechanically Ventilated Patients
Joint Authors
van der Zee, Philip
van Walree, Inez
Fijen, Jan-Willem
van Houte, Arend-Jan
van Velzen-Blad, Heleen
Rijkers, Ger
Gommers, Diederik
Endeman, Henrik
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-11
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
Exhaled breath condensate (EBC) is a noninvasive method to collect samples from the respiratory tract.
Usually, a thermoelectric cooling module is required to collect sufficient EBC volume for analyses.
In here, we assessed the feasibility of cytokine and chemokine detection in EBC collected directly from the ventilator circuit without the use of a cooling module: swivel-derived exhaled breath condensate (SEBC).
Methods.
SEBC was prospectively collected from the swivel adapter and stored at -80°C.
The objective of this study was to detect cytokines and chemokines in SEBC with a multiplex immunoassay.
Secondary outcomes were to assess the correlation between cytokine and chemokine concentrations in SEBC and mechanical ventilation parameters, systemic inflammation parameters, and hemodynamic parameters.
Results.
Twenty-nine SEBC samples were obtained from 13 ICU patients.
IL-1β, IL-4, IL-8, and IL-17 were detected in more than 90% of SEBC samples, and significant correlations between multiple cytokines and chemokines were found.
Several significant correlations were found between cytokines and chemokines in SEBC and mechanical ventilation parameters and serum lactate concentrations.
Conclusion.
This pilot study showed that it is feasible to detect cytokines and chemokines in SEBC samples obtained without a cooling module.
Despite small sample size, correlations were found between cytokines and chemokines in SEBC and mechanical ventilation parameters, as well as serum lactate concentrations.
This simple SEBC collection method provides the opportunity to collect EBC samples in large prospective ICU cohorts.
American Psychological Association (APA)
van der Zee, Philip& van Walree, Inez& Fijen, Jan-Willem& van Houte, Arend-Jan& van Velzen-Blad, Heleen& Rijkers, Ger…[et al.]. 2020. Cytokines and Chemokines Are Detectable in Swivel-Derived Exhaled Breath Condensate (SEBC): A Pilot Study in Mechanically Ventilated Patients. Disease Markers،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1153803
Modern Language Association (MLA)
van der Zee, Philip…[et al.]. Cytokines and Chemokines Are Detectable in Swivel-Derived Exhaled Breath Condensate (SEBC): A Pilot Study in Mechanically Ventilated Patients. Disease Markers No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1153803
American Medical Association (AMA)
van der Zee, Philip& van Walree, Inez& Fijen, Jan-Willem& van Houte, Arend-Jan& van Velzen-Blad, Heleen& Rijkers, Ger…[et al.]. Cytokines and Chemokines Are Detectable in Swivel-Derived Exhaled Breath Condensate (SEBC): A Pilot Study in Mechanically Ventilated Patients. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1153803
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153803