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Clinical Significance and Prognostic Value of miR-28-5p in Colon Cancer
المؤلفون المشاركون
Chen, Ying
Li, Ji-lin
Li, Ke-zhi
Xie, Ming-zhi
Tang, Yan-ping
Hu, Bangli
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-20
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
The association of miR-28-5p with colon cancer remains to be elucidated.
This study aimed to determine the clinical significance and prognostic value of miR-28-5p in colon cancer.
Methods.
We retrospectively analyzed the data of miR-28-5p in colon adenocarcinoma data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO), and the data was divided into cancer group and normal group, respectively.
Forty colon cancer tissues and adjacent normal tissues were collected and tested by qRT-PCR methods.
The difference of the miR-28-5p expression between colon cancer and normal tissues was compared.
The clinical significance of miR-28-5p in colon cancer and the association with the survival were determined.
The predictive value of miR-28-5p in clinical features was determined using receiver operating characteristic curve.
The target genes of miR-28-5p were identified, and the functional of target genes was performed using bioinformatics analysis.
Results: The expression of miR-28-5p was increased in colon cancer tissues compared with normal controls (p=0.037).
The expression of miR-28-5p was significantly increased in tissues with distant metastases compared with that without distant metastases (p=0.026).
Patients with high expression of miR-28-5p have a shorter survival time than those with low expression (p=0.004).
Cox analysis showed that miR-28-5p was an independent predictor for the survival of patients (p=0.014).
Combination of miR-28-5p with TNM stage and clinical stage can improve the prognostic value for the patients (p<0.05).
miR-28-5p has a moderate predictive value in predicting the TNM stage and clinical stage (T stage: AUC=0.515; N stage: AUC=0.523, M stage: AUC=0.572; clinical stage: AUC=0.539).
711 potential target genes of miR-28-5p were screened; their function and pathways were identified.
Conclusions: This study demonstrated that miR-28-5p was increased in colon cancer and can be an independent indicator for the overall survival in patients with colon cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Ji-lin& Li, Ke-zhi& Xie, Ming-zhi& Tang, Yan-ping& Chen, Ying& Hu, Bangli. 2020. Clinical Significance and Prognostic Value of miR-28-5p in Colon Cancer. Disease Markers،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1153815
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Ji-lin…[et al.]. Clinical Significance and Prognostic Value of miR-28-5p in Colon Cancer. Disease Markers No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1153815
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Ji-lin& Li, Ke-zhi& Xie, Ming-zhi& Tang, Yan-ping& Chen, Ying& Hu, Bangli. Clinical Significance and Prognostic Value of miR-28-5p in Colon Cancer. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1153815
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153815
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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