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The Proliferation Enhancing Effects of Salidroside on Schwann Cells In Vitro
المؤلفون المشاركون
Liu, Hui
Lv, Peizhen
Wu, Huayu
Zhang, Kun
Xu, Fuben
Zheng, Li
Zhao, Jinmin
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-07
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Derived from Rhodiola rosea L., which is a popular plant in Eastern Europe and Asia, salidroside has pharmacological properties including antiviral, anticancer, hepatoprotective, antidiabetic, and antioxidative effects.
Recent studies show that salidroside has neurotrophic and neuroprotective effects.
However, the effect of salidroside on Schwann cells (SCs) and the underlying mechanisms of the salidroside-induced neurotrophin secretion have seldom been studied.
In this study, the effect of salidroside on the survival, proliferation, and gene expression of Schwann cells lineage (RSC96) was studied through the examinations of the cell viability, proliferation, morphology, and expression of neurotrophic factor related genes including BDNF, GDNF, and CDNF at 2, 4, and 6 days, respectively.
These results showed that salidroside significantly enhanced survival and proliferation of SCs.
The underlying mechanism might involve that salidroside affected SCs growth through the modulation of several neurotrophic factors including BDNF, GDNF, and CDNF.
As for the concentration, 0.4 mM, 0.2 mM, and 0.1 mM of salidroside were recommended, especially 0.2 mM.
This investigation indicates that salidroside is capable of enhancing SCs survival and function in vitro, which highlights the possibility that salidroside as a drug agent to promote nerve regeneration in cellular nerve scaffold through salidroside-induced neurotrophin secretion in SCs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Hui& Lv, Peizhen& Wu, Huayu& Zhang, Kun& Xu, Fuben& Zheng, Li…[et al.]. 2017. The Proliferation Enhancing Effects of Salidroside on Schwann Cells In Vitro. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1153832
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Hui…[et al.]. The Proliferation Enhancing Effects of Salidroside on Schwann Cells In Vitro. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1153832
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Hui& Lv, Peizhen& Wu, Huayu& Zhang, Kun& Xu, Fuben& Zheng, Li…[et al.]. The Proliferation Enhancing Effects of Salidroside on Schwann Cells In Vitro. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1153832
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153832
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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