The Proliferation Enhancing Effects of Salidroside on Schwann Cells In Vitro
Joint Authors
Liu, Hui
Lv, Peizhen
Wu, Huayu
Zhang, Kun
Xu, Fuben
Zheng, Li
Zhao, Jinmin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Derived from Rhodiola rosea L., which is a popular plant in Eastern Europe and Asia, salidroside has pharmacological properties including antiviral, anticancer, hepatoprotective, antidiabetic, and antioxidative effects.
Recent studies show that salidroside has neurotrophic and neuroprotective effects.
However, the effect of salidroside on Schwann cells (SCs) and the underlying mechanisms of the salidroside-induced neurotrophin secretion have seldom been studied.
In this study, the effect of salidroside on the survival, proliferation, and gene expression of Schwann cells lineage (RSC96) was studied through the examinations of the cell viability, proliferation, morphology, and expression of neurotrophic factor related genes including BDNF, GDNF, and CDNF at 2, 4, and 6 days, respectively.
These results showed that salidroside significantly enhanced survival and proliferation of SCs.
The underlying mechanism might involve that salidroside affected SCs growth through the modulation of several neurotrophic factors including BDNF, GDNF, and CDNF.
As for the concentration, 0.4 mM, 0.2 mM, and 0.1 mM of salidroside were recommended, especially 0.2 mM.
This investigation indicates that salidroside is capable of enhancing SCs survival and function in vitro, which highlights the possibility that salidroside as a drug agent to promote nerve regeneration in cellular nerve scaffold through salidroside-induced neurotrophin secretion in SCs.
American Psychological Association (APA)
Liu, Hui& Lv, Peizhen& Wu, Huayu& Zhang, Kun& Xu, Fuben& Zheng, Li…[et al.]. 2017. The Proliferation Enhancing Effects of Salidroside on Schwann Cells In Vitro. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1153832
Modern Language Association (MLA)
Liu, Hui…[et al.]. The Proliferation Enhancing Effects of Salidroside on Schwann Cells In Vitro. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1153832
American Medical Association (AMA)
Liu, Hui& Lv, Peizhen& Wu, Huayu& Zhang, Kun& Xu, Fuben& Zheng, Li…[et al.]. The Proliferation Enhancing Effects of Salidroside on Schwann Cells In Vitro. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1153832
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153832