Assessment of Toxicity and Beneficiary Effects of Garcinia pedunculata on the Hematological, Biochemical, and Histological Homeostasis in Rats
المؤلفون المشاركون
Tanvir, E. M.
Khalil, Md. Ibrahim
Saha, Moumoni
Rumpa, Nur-E-Noushin
Hossen, Md. Sakib
Ali, Md. Yousuf
Bhoumik, Nikhil Chandra
Paul, Sudip
Gan, Siew Hua
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-22
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
This study was undertaken to investigate the toxicological profile of a methanolic extract of Garcinia pedunculata fruit in rats by conducting hematological, biochemical, and histopathological examinations.
Long Evans rats were divided into four groups, each with 6 animals, and were treated with three oral doses (250, 500, and 1000 mg/kg) once daily for 21 days.
The extract did not cause significant changes in body and relative organ weight, percent water content, or hematological parameters at any administered doses.
However, a significant dose-dependent positive effect in serum lipid profile and all atherogenic indices including the cardiac risk ratio, Castelli’s risk index-2, and the atherogenic coefficient were observed.
Significant increases in the levels of iron and decreases in serum alkaline phosphatase, alanine transaminase, and lactate dehydrogenase activities and the levels of serum glucose were noted when the extract was administered at the highest dose (1000 mg/kg).
Histopathological examination of the target tissues further confirmed that the extract was safe and had no observed toxicological features.
Our study indicates that G.
pedunculata fruit is nontoxic, has the potential to be effective against atherosclerosis, and may be used as a hepatoprotectant.
The fruit extract is also beneficial to those with iron deficiency and hyperglycemia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Paul, Sudip& Ali, Md. Yousuf& Rumpa, Nur-E-Noushin& Tanvir, E. M.& Hossen, Md. Sakib& Saha, Moumoni…[et al.]. 2017. Assessment of Toxicity and Beneficiary Effects of Garcinia pedunculata on the Hematological, Biochemical, and Histological Homeostasis in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1153840
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Paul, Sudip…[et al.]. Assessment of Toxicity and Beneficiary Effects of Garcinia pedunculata on the Hematological, Biochemical, and Histological Homeostasis in Rats. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1153840
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Paul, Sudip& Ali, Md. Yousuf& Rumpa, Nur-E-Noushin& Tanvir, E. M.& Hossen, Md. Sakib& Saha, Moumoni…[et al.]. Assessment of Toxicity and Beneficiary Effects of Garcinia pedunculata on the Hematological, Biochemical, and Histological Homeostasis in Rats. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1153840
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153840
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر