Assessment of Toxicity and Beneficiary Effects of Garcinia pedunculata on the Hematological, Biochemical, and Histological Homeostasis in Rats
Joint Authors
Tanvir, E. M.
Khalil, Md. Ibrahim
Saha, Moumoni
Rumpa, Nur-E-Noushin
Hossen, Md. Sakib
Ali, Md. Yousuf
Bhoumik, Nikhil Chandra
Paul, Sudip
Gan, Siew Hua
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-22
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
This study was undertaken to investigate the toxicological profile of a methanolic extract of Garcinia pedunculata fruit in rats by conducting hematological, biochemical, and histopathological examinations.
Long Evans rats were divided into four groups, each with 6 animals, and were treated with three oral doses (250, 500, and 1000 mg/kg) once daily for 21 days.
The extract did not cause significant changes in body and relative organ weight, percent water content, or hematological parameters at any administered doses.
However, a significant dose-dependent positive effect in serum lipid profile and all atherogenic indices including the cardiac risk ratio, Castelli’s risk index-2, and the atherogenic coefficient were observed.
Significant increases in the levels of iron and decreases in serum alkaline phosphatase, alanine transaminase, and lactate dehydrogenase activities and the levels of serum glucose were noted when the extract was administered at the highest dose (1000 mg/kg).
Histopathological examination of the target tissues further confirmed that the extract was safe and had no observed toxicological features.
Our study indicates that G.
pedunculata fruit is nontoxic, has the potential to be effective against atherosclerosis, and may be used as a hepatoprotectant.
The fruit extract is also beneficial to those with iron deficiency and hyperglycemia.
American Psychological Association (APA)
Paul, Sudip& Ali, Md. Yousuf& Rumpa, Nur-E-Noushin& Tanvir, E. M.& Hossen, Md. Sakib& Saha, Moumoni…[et al.]. 2017. Assessment of Toxicity and Beneficiary Effects of Garcinia pedunculata on the Hematological, Biochemical, and Histological Homeostasis in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1153840
Modern Language Association (MLA)
Paul, Sudip…[et al.]. Assessment of Toxicity and Beneficiary Effects of Garcinia pedunculata on the Hematological, Biochemical, and Histological Homeostasis in Rats. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1153840
American Medical Association (AMA)
Paul, Sudip& Ali, Md. Yousuf& Rumpa, Nur-E-Noushin& Tanvir, E. M.& Hossen, Md. Sakib& Saha, Moumoni…[et al.]. Assessment of Toxicity and Beneficiary Effects of Garcinia pedunculata on the Hematological, Biochemical, and Histological Homeostasis in Rats. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1153840
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153840