The Prognostic Significance of Combined Pretreatment Fibrinogen and Neutrophil-Lymphocyte Ratio in Various Cancers: A Systematic Review and Meta-Analysis

الملخص EN

Purpose.

The prognostic value of a new scoring system, termed F-NLR, that combines pretreatment fibrinogen level with neutrophil-lymphocyte ratio has been evaluated in various cancers.

However, the results are controversial.

The purpose of this study was to comprehensively analyze the prognostic value of F-NLR score in patients with cancers.

Methods.

An integrated search of relevant studies was conducted by screening the PubMed and Embase databases.

Pooled hazard ratios, with 95% confidence intervals (CIs), for overall survival (OS) and disease-free survival (DFS)/progression-free survival (PFS) were calculated to estimate the prognostic significance of F-NLR score in patients with various tumors.

A random effects model was used for comprehensive analysis, and subgroup and meta-regression analyses were used to explore sources of heterogeneity.

Results.

Thirteen articles reporting data from of 4747 patients were included in the study.

Pooled analysis revealed that high F-NLR score was significantly associated with poor OS (HR=1.77; 95% CI, 1.51–2.08) and poor DFS/PFS (HR=1.63; 95% CI, 1.30–2.05).

Subgroup and meta-regression analyses did not alter the prognostic role of F-NLR score in OS and DFS/PFS.

Conclusions.

Increased F-NLR score is significantly associated with poor prognosis in patients with cancers and can serve as an effective prognostic indicator.