Antifungal Activity of the Ethanol Extract from Flos Rosae Chinensis with Activity against Fluconazole-Resistant Clinical Candida
المؤلفون المشاركون
Liu, Wei
Zhang, Lulu
Lin, Hui
Dai, Baodi
Yan, Lan
Cao, YongBing
Jiang, Yuan-Ying
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-20
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
This study was designed to investigate the antifungal activity of a hydroalcoholic extract from Flos Rosae Chinensis (FRC) combined with fluconazole (FCZ) against clinical isolates of Candida albicans resistant to FCZ.
The minimum inhibitory concentration (MIC) of FRC was determined using a checkerboard microdilution assay.
The synergistic effects of the combination of FRC and FCZ against clinical isolates of C.
albicans resistant to FCZ were further confirmed by constructing time-growth curves and performing an agar diffusion test.
FRC alone exerted efficient antifungal activities against C.
albicans within a MIC80 ranging from 20 μg/ml to 40 μg/ml.
FRC failed to enhance the effects of FCZ against sensitive C.
albicans strains, although it rendered FCZ-resistant C.
albicans more sensitive.
These results were further confirmed by the result of in vivo study.
Our study is the first to discover that FRC can inhibit the growth of C.
albicans to a certain degree.
An FRC antifungal mechanism study showed that FRC strengthens FCZ to inhibit the action of ergosterol biosynthesis by promoting the transformation of lanosterol to eburicol, suggesting that the antifungal mechanism of FRC involves the inhibition of ergosterol biosynthesis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Lulu& Lin, Hui& Liu, Wei& Dai, Baodi& Yan, Lan& Cao, YongBing…[et al.]. 2017. Antifungal Activity of the Ethanol Extract from Flos Rosae Chinensis with Activity against Fluconazole-Resistant Clinical Candida. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1153885
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Lulu…[et al.]. Antifungal Activity of the Ethanol Extract from Flos Rosae Chinensis with Activity against Fluconazole-Resistant Clinical Candida. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1153885
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Lulu& Lin, Hui& Liu, Wei& Dai, Baodi& Yan, Lan& Cao, YongBing…[et al.]. Antifungal Activity of the Ethanol Extract from Flos Rosae Chinensis with Activity against Fluconazole-Resistant Clinical Candida. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1153885
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153885
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر