Antifungal Activity of the Ethanol Extract from Flos Rosae Chinensis with Activity against Fluconazole-Resistant Clinical Candida
Joint Authors
Liu, Wei
Zhang, Lulu
Lin, Hui
Dai, Baodi
Yan, Lan
Cao, YongBing
Jiang, Yuan-Ying
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
This study was designed to investigate the antifungal activity of a hydroalcoholic extract from Flos Rosae Chinensis (FRC) combined with fluconazole (FCZ) against clinical isolates of Candida albicans resistant to FCZ.
The minimum inhibitory concentration (MIC) of FRC was determined using a checkerboard microdilution assay.
The synergistic effects of the combination of FRC and FCZ against clinical isolates of C.
albicans resistant to FCZ were further confirmed by constructing time-growth curves and performing an agar diffusion test.
FRC alone exerted efficient antifungal activities against C.
albicans within a MIC80 ranging from 20 μg/ml to 40 μg/ml.
FRC failed to enhance the effects of FCZ against sensitive C.
albicans strains, although it rendered FCZ-resistant C.
albicans more sensitive.
These results were further confirmed by the result of in vivo study.
Our study is the first to discover that FRC can inhibit the growth of C.
albicans to a certain degree.
An FRC antifungal mechanism study showed that FRC strengthens FCZ to inhibit the action of ergosterol biosynthesis by promoting the transformation of lanosterol to eburicol, suggesting that the antifungal mechanism of FRC involves the inhibition of ergosterol biosynthesis.
American Psychological Association (APA)
Zhang, Lulu& Lin, Hui& Liu, Wei& Dai, Baodi& Yan, Lan& Cao, YongBing…[et al.]. 2017. Antifungal Activity of the Ethanol Extract from Flos Rosae Chinensis with Activity against Fluconazole-Resistant Clinical Candida. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1153885
Modern Language Association (MLA)
Zhang, Lulu…[et al.]. Antifungal Activity of the Ethanol Extract from Flos Rosae Chinensis with Activity against Fluconazole-Resistant Clinical Candida. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1153885
American Medical Association (AMA)
Zhang, Lulu& Lin, Hui& Liu, Wei& Dai, Baodi& Yan, Lan& Cao, YongBing…[et al.]. Antifungal Activity of the Ethanol Extract from Flos Rosae Chinensis with Activity against Fluconazole-Resistant Clinical Candida. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1153885
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153885