Expression and Significance of Insulin Receptor Substrate 1 in Human Hepatocellular Carcinoma
المؤلفون المشاركون
Gao, Chun
Zhang, Hui
Zhang, Wei-Shuo
Fang, Long
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-07-10
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Insulin receptor substrate 1 (IRS-1) is an important molecule of the insulin signal transduction pathway and has been associated with the occurrence and development of many tumors, including hepatocellular carcinoma (HCC).
Our study was designed to determine the expression and significance of IRS-1 in human HCC.
Methods.
Two hundred and forty specimens were drawn from 140 patients, including 100 HCC tissues and 100 paracancerous (PC) tissues from 100 HCC patients, 20 liver cirrhosis (LC) tissues from 20 LC patients, and 20 chronic hepatitis (CH) tissues from 20 CH patients.
Baseline and pathological characteristics were included, and the expression of IRS-1 was examined by immunohistochemical (IHC) staining.
Binary logistic regression model calculation was used for multivariate analysis.
Results.
The total positive rates of IRS-1 expression were 41.0%, 17.0%, 15.0%, and 10.0% in HCC, PC, LC and CH tissues, respectively.
IRS-1-positive signals were brown in color and located in the nucleus and cytoplasm.
Compared with PC, LC, and CH tissues, a significantly increased expression was observed in human HCC tissues (P<0.001, P=0.028, and P=0.008).
Eight of the total 240 specimens had the strong immunostaining of IRS-1 expression, and all of them were HCC tissues.
After control of the age, gender, and HBV and HCV infection, IRS-1 expression was independently associated with the diagnosis of HCC (OR 6.60, 95% CI 2.243-19.425, P=0.001).
Conclusions.
Positive expression of IRS-1 in HCC was increased significantly and may play an important role in the occurrence and development of human HCC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gao, Chun& Zhang, Hui& Zhang, Wei-Shuo& Fang, Long. 2020. Expression and Significance of Insulin Receptor Substrate 1 in Human Hepatocellular Carcinoma. Disease Markers،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1153980
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gao, Chun…[et al.]. Expression and Significance of Insulin Receptor Substrate 1 in Human Hepatocellular Carcinoma. Disease Markers No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1153980
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gao, Chun& Zhang, Hui& Zhang, Wei-Shuo& Fang, Long. Expression and Significance of Insulin Receptor Substrate 1 in Human Hepatocellular Carcinoma. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1153980
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153980
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر