Expression and Significance of Insulin Receptor Substrate 1 in Human Hepatocellular Carcinoma
Joint Authors
Gao, Chun
Zhang, Hui
Zhang, Wei-Shuo
Fang, Long
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Insulin receptor substrate 1 (IRS-1) is an important molecule of the insulin signal transduction pathway and has been associated with the occurrence and development of many tumors, including hepatocellular carcinoma (HCC).
Our study was designed to determine the expression and significance of IRS-1 in human HCC.
Methods.
Two hundred and forty specimens were drawn from 140 patients, including 100 HCC tissues and 100 paracancerous (PC) tissues from 100 HCC patients, 20 liver cirrhosis (LC) tissues from 20 LC patients, and 20 chronic hepatitis (CH) tissues from 20 CH patients.
Baseline and pathological characteristics were included, and the expression of IRS-1 was examined by immunohistochemical (IHC) staining.
Binary logistic regression model calculation was used for multivariate analysis.
Results.
The total positive rates of IRS-1 expression were 41.0%, 17.0%, 15.0%, and 10.0% in HCC, PC, LC and CH tissues, respectively.
IRS-1-positive signals were brown in color and located in the nucleus and cytoplasm.
Compared with PC, LC, and CH tissues, a significantly increased expression was observed in human HCC tissues (P<0.001, P=0.028, and P=0.008).
Eight of the total 240 specimens had the strong immunostaining of IRS-1 expression, and all of them were HCC tissues.
After control of the age, gender, and HBV and HCV infection, IRS-1 expression was independently associated with the diagnosis of HCC (OR 6.60, 95% CI 2.243-19.425, P=0.001).
Conclusions.
Positive expression of IRS-1 in HCC was increased significantly and may play an important role in the occurrence and development of human HCC.
American Psychological Association (APA)
Gao, Chun& Zhang, Hui& Zhang, Wei-Shuo& Fang, Long. 2020. Expression and Significance of Insulin Receptor Substrate 1 in Human Hepatocellular Carcinoma. Disease Markers،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1153980
Modern Language Association (MLA)
Gao, Chun…[et al.]. Expression and Significance of Insulin Receptor Substrate 1 in Human Hepatocellular Carcinoma. Disease Markers No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1153980
American Medical Association (AMA)
Gao, Chun& Zhang, Hui& Zhang, Wei-Shuo& Fang, Long. Expression and Significance of Insulin Receptor Substrate 1 in Human Hepatocellular Carcinoma. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1153980
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153980