Association of the Expression Level of miR-16 with Prognosis of Solid Cancer Patients: A Meta-Analysis and Bioinformatic Analysis
المؤلفون المشاركون
Jiang, Danjie
Zhou, Feixiang
Zhang, Wanting
Mao, Yingying
Ye, Ding
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-07-25
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
To assess the association between the expression level of miR-16 and prognosis of solid cancer patients by meta-analysis and bioinformatic analysis.
Methods.
PubMed, Web of Science, and Embase databases were searched until October 31, 2019, to identify eligible studies reporting the association of the miR-16 status with the prognosis of solid cancer patients.
Hazard ratios (HRs) with 95% confidence intervals (CIs) were pooled, and a heterogeneity test was conducted.
Sensitivity analysis and a publication bias test were also carried out.
Furthermore, the miRpower database was used to validate the association.
Results.
Thirteen articles with 2303 solid cancer patients were included in the meta-analysis.
Solid cancer patients with low expression level of miR-16 had shorter survival time (I2=84.0%, HR=1.47, 95% CI: 1.13-1.91, P=0.004).
In the subgroup analyses of cancer sites, low miR-16 expression level was associated with poor prognosis in the reproductive system cancers (I2=33.3%, HR=1.24, 95% CI: 1.06-1.45, P=0.008).
Sensitivity analysis suggested that the pooled HR was stable and omitting a single study did not change the significance of the pooled HR.
Begg’s test and Egger’s test revealed no publication bias in the meta-analysis.
In bioinformatic analysis, the significant association between miR-16 level and prognosis of patients with reproductive system cancers was further confirmed (HR=1.21, 95% CI: 1.03-1.42, P=0.017).
Conclusion.
Low expression level of miR-16 is an indicator for poor prognosis of solid cancer patients, particularly in reproductive system cancers.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Wanting& Zhou, Feixiang& Jiang, Danjie& Mao, Yingying& Ye, Ding. 2020. Association of the Expression Level of miR-16 with Prognosis of Solid Cancer Patients: A Meta-Analysis and Bioinformatic Analysis. Disease Markers،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1154055
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Wanting…[et al.]. Association of the Expression Level of miR-16 with Prognosis of Solid Cancer Patients: A Meta-Analysis and Bioinformatic Analysis. Disease Markers No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1154055
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Wanting& Zhou, Feixiang& Jiang, Danjie& Mao, Yingying& Ye, Ding. Association of the Expression Level of miR-16 with Prognosis of Solid Cancer Patients: A Meta-Analysis and Bioinformatic Analysis. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1154055
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154055
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر