Association of the Expression Level of miR-16 with Prognosis of Solid Cancer Patients: A Meta-Analysis and Bioinformatic Analysis
Joint Authors
Jiang, Danjie
Zhou, Feixiang
Zhang, Wanting
Mao, Yingying
Ye, Ding
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
To assess the association between the expression level of miR-16 and prognosis of solid cancer patients by meta-analysis and bioinformatic analysis.
Methods.
PubMed, Web of Science, and Embase databases were searched until October 31, 2019, to identify eligible studies reporting the association of the miR-16 status with the prognosis of solid cancer patients.
Hazard ratios (HRs) with 95% confidence intervals (CIs) were pooled, and a heterogeneity test was conducted.
Sensitivity analysis and a publication bias test were also carried out.
Furthermore, the miRpower database was used to validate the association.
Results.
Thirteen articles with 2303 solid cancer patients were included in the meta-analysis.
Solid cancer patients with low expression level of miR-16 had shorter survival time (I2=84.0%, HR=1.47, 95% CI: 1.13-1.91, P=0.004).
In the subgroup analyses of cancer sites, low miR-16 expression level was associated with poor prognosis in the reproductive system cancers (I2=33.3%, HR=1.24, 95% CI: 1.06-1.45, P=0.008).
Sensitivity analysis suggested that the pooled HR was stable and omitting a single study did not change the significance of the pooled HR.
Begg’s test and Egger’s test revealed no publication bias in the meta-analysis.
In bioinformatic analysis, the significant association between miR-16 level and prognosis of patients with reproductive system cancers was further confirmed (HR=1.21, 95% CI: 1.03-1.42, P=0.017).
Conclusion.
Low expression level of miR-16 is an indicator for poor prognosis of solid cancer patients, particularly in reproductive system cancers.
American Psychological Association (APA)
Zhang, Wanting& Zhou, Feixiang& Jiang, Danjie& Mao, Yingying& Ye, Ding. 2020. Association of the Expression Level of miR-16 with Prognosis of Solid Cancer Patients: A Meta-Analysis and Bioinformatic Analysis. Disease Markers،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1154055
Modern Language Association (MLA)
Zhang, Wanting…[et al.]. Association of the Expression Level of miR-16 with Prognosis of Solid Cancer Patients: A Meta-Analysis and Bioinformatic Analysis. Disease Markers No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1154055
American Medical Association (AMA)
Zhang, Wanting& Zhou, Feixiang& Jiang, Danjie& Mao, Yingying& Ye, Ding. Association of the Expression Level of miR-16 with Prognosis of Solid Cancer Patients: A Meta-Analysis and Bioinformatic Analysis. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1154055
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154055