Manuka Honey Exerts Antioxidant and Anti-Inflammatory Activities That Promote Healing of Acetic Acid-Induced Gastric Ulcer in Rats
المؤلفون المشاركون
Kamal, Mohammad Amjad
Abbas, Aymn T.
El-Shitany, Nagla A.
Ali, Soad S.
Abdel-dayem, Umama A.
Almasaudi, Saad B.
Harakeh, Steve
Al-Hindi, Rashad R.
Saleh, Rasha M.
Al Jaouni, Soad K.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-19
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Gastric ulcers are a major problem worldwide with no effective treatment.
The objective of this study was to evaluate the use of manuka honey in the treatment of acetic acid-induced chronic gastric ulcers in rats.
Different groups of rats were treated with three different concentrations of honey.
Stomachs were checked macroscopically for ulcerative lesions in the glandular mucosa and microscopically for histopathological alterations.
Treatment with manuka honey significantly reduced the ulcer index and maintained the glycoprotein content.
It also reduced the mucosal myeloperoxidase activity, lipid peroxidation (MDA), and the inflammatory cytokines (TNF-α, IL-1β, and IL-6) as compared to untreated control group.
In addition, honey-treated groups showed significant increase in enzymatic (GPx and SOD) and nonenzymatic (GSH) antioxidants besides levels of the anti-inflammatory cytokine IL-10.
Flow cytometry studies showed that treatment of animals with manuka honey has normalized cell cycle distribution and significantly lowered apoptosis in gastric mucosa.
In conclusion, the results indicated that manuka honey is effective in the treatment of chronic ulcer and preservation of mucosal glycoproteins.
Its effects are due to its antioxidant and anti-inflammatory properties that resulted in a significant reduction of the gastric mucosal MDA, TNF-α, IL-1β, and IL-6 and caused an elevation in IL-10 levels.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Almasaudi, Saad B.& Abbas, Aymn T.& Al-Hindi, Rashad R.& El-Shitany, Nagla A.& Abdel-dayem, Umama A.& Ali, Soad S.…[et al.]. 2017. Manuka Honey Exerts Antioxidant and Anti-Inflammatory Activities That Promote Healing of Acetic Acid-Induced Gastric Ulcer in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1154060
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Almasaudi, Saad B.…[et al.]. Manuka Honey Exerts Antioxidant and Anti-Inflammatory Activities That Promote Healing of Acetic Acid-Induced Gastric Ulcer in Rats. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1154060
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Almasaudi, Saad B.& Abbas, Aymn T.& Al-Hindi, Rashad R.& El-Shitany, Nagla A.& Abdel-dayem, Umama A.& Ali, Soad S.…[et al.]. Manuka Honey Exerts Antioxidant and Anti-Inflammatory Activities That Promote Healing of Acetic Acid-Induced Gastric Ulcer in Rats. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1154060
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154060
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر