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Manuka Honey Exerts Antioxidant and Anti-Inflammatory Activities That Promote Healing of Acetic Acid-Induced Gastric Ulcer in Rats
Joint Authors
Kamal, Mohammad Amjad
Abbas, Aymn T.
El-Shitany, Nagla A.
Ali, Soad S.
Abdel-dayem, Umama A.
Almasaudi, Saad B.
Harakeh, Steve
Al-Hindi, Rashad R.
Saleh, Rasha M.
Al Jaouni, Soad K.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Gastric ulcers are a major problem worldwide with no effective treatment.
The objective of this study was to evaluate the use of manuka honey in the treatment of acetic acid-induced chronic gastric ulcers in rats.
Different groups of rats were treated with three different concentrations of honey.
Stomachs were checked macroscopically for ulcerative lesions in the glandular mucosa and microscopically for histopathological alterations.
Treatment with manuka honey significantly reduced the ulcer index and maintained the glycoprotein content.
It also reduced the mucosal myeloperoxidase activity, lipid peroxidation (MDA), and the inflammatory cytokines (TNF-α, IL-1β, and IL-6) as compared to untreated control group.
In addition, honey-treated groups showed significant increase in enzymatic (GPx and SOD) and nonenzymatic (GSH) antioxidants besides levels of the anti-inflammatory cytokine IL-10.
Flow cytometry studies showed that treatment of animals with manuka honey has normalized cell cycle distribution and significantly lowered apoptosis in gastric mucosa.
In conclusion, the results indicated that manuka honey is effective in the treatment of chronic ulcer and preservation of mucosal glycoproteins.
Its effects are due to its antioxidant and anti-inflammatory properties that resulted in a significant reduction of the gastric mucosal MDA, TNF-α, IL-1β, and IL-6 and caused an elevation in IL-10 levels.
American Psychological Association (APA)
Almasaudi, Saad B.& Abbas, Aymn T.& Al-Hindi, Rashad R.& El-Shitany, Nagla A.& Abdel-dayem, Umama A.& Ali, Soad S.…[et al.]. 2017. Manuka Honey Exerts Antioxidant and Anti-Inflammatory Activities That Promote Healing of Acetic Acid-Induced Gastric Ulcer in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1154060
Modern Language Association (MLA)
Almasaudi, Saad B.…[et al.]. Manuka Honey Exerts Antioxidant and Anti-Inflammatory Activities That Promote Healing of Acetic Acid-Induced Gastric Ulcer in Rats. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1154060
American Medical Association (AMA)
Almasaudi, Saad B.& Abbas, Aymn T.& Al-Hindi, Rashad R.& El-Shitany, Nagla A.& Abdel-dayem, Umama A.& Ali, Soad S.…[et al.]. Manuka Honey Exerts Antioxidant and Anti-Inflammatory Activities That Promote Healing of Acetic Acid-Induced Gastric Ulcer in Rats. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1154060
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154060