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Therapeutic Effects of Fermented Flax Seed Oil on NCNga Mice with Atopic Dermatitis-Like Skin Lesions
المؤلفون المشاركون
Hong, Seung-Ug
Yang, Joonhyoung
Min, Sangyeon
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-19
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Atopic Dermatitis (AD) is one of the most common chronic inflammatory skin diseases.
Objective.
This experiment aimed to study the effects of Fermented Flax Seed Oil (FFSO) on symptoms such as redness, eczema, and pruritus induced by AD.
Materials and Methods.
AD-induced NC/Nga mice were used to observe the immunological and therapeutic effects of FFSO on skin in vivo.
Raw 264.7 cells were used to investigate the effects of FFSO in cells.
Fc receptor expression and concentration of beta-hexosaminidase were measured.
Nitric oxide assay, Western blotting, real-time PCR, image analysis, and statistical analysis were performed in vitro.
Results.
In the immunohistochemical results, p-ERK 1/2 expression decreased, fibrogenesis strongly increased, and distribution reduction is observed.
Distribution of IL-4-positive cells in the corium near the basal portion of the epithelium in the AT group was reduced.
FFSO treatment reduced the number of cells showing NF-κB p65 and iNOS expression.
The level of LXR in the AT group was higher than that in the AE group, and elevation of PKC expression was significantly reduced by FFSO treatment.
Conclusion.
FFSO could alleviate symptoms of AD such as epithelial damage, redness, swelling, and pruritus.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Joonhyoung& Min, Sangyeon& Hong, Seung-Ug. 2017. Therapeutic Effects of Fermented Flax Seed Oil on NCNga Mice with Atopic Dermatitis-Like Skin Lesions. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1154074
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Joonhyoung…[et al.]. Therapeutic Effects of Fermented Flax Seed Oil on NCNga Mice with Atopic Dermatitis-Like Skin Lesions. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1154074
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Joonhyoung& Min, Sangyeon& Hong, Seung-Ug. Therapeutic Effects of Fermented Flax Seed Oil on NCNga Mice with Atopic Dermatitis-Like Skin Lesions. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1154074
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154074
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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