Therapeutic Effects of Fermented Flax Seed Oil on NCNga Mice with Atopic Dermatitis-Like Skin Lesions
Joint Authors
Hong, Seung-Ug
Yang, Joonhyoung
Min, Sangyeon
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Atopic Dermatitis (AD) is one of the most common chronic inflammatory skin diseases.
Objective.
This experiment aimed to study the effects of Fermented Flax Seed Oil (FFSO) on symptoms such as redness, eczema, and pruritus induced by AD.
Materials and Methods.
AD-induced NC/Nga mice were used to observe the immunological and therapeutic effects of FFSO on skin in vivo.
Raw 264.7 cells were used to investigate the effects of FFSO in cells.
Fc receptor expression and concentration of beta-hexosaminidase were measured.
Nitric oxide assay, Western blotting, real-time PCR, image analysis, and statistical analysis were performed in vitro.
Results.
In the immunohistochemical results, p-ERK 1/2 expression decreased, fibrogenesis strongly increased, and distribution reduction is observed.
Distribution of IL-4-positive cells in the corium near the basal portion of the epithelium in the AT group was reduced.
FFSO treatment reduced the number of cells showing NF-κB p65 and iNOS expression.
The level of LXR in the AT group was higher than that in the AE group, and elevation of PKC expression was significantly reduced by FFSO treatment.
Conclusion.
FFSO could alleviate symptoms of AD such as epithelial damage, redness, swelling, and pruritus.
American Psychological Association (APA)
Yang, Joonhyoung& Min, Sangyeon& Hong, Seung-Ug. 2017. Therapeutic Effects of Fermented Flax Seed Oil on NCNga Mice with Atopic Dermatitis-Like Skin Lesions. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1154074
Modern Language Association (MLA)
Yang, Joonhyoung…[et al.]. Therapeutic Effects of Fermented Flax Seed Oil on NCNga Mice with Atopic Dermatitis-Like Skin Lesions. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1154074
American Medical Association (AMA)
Yang, Joonhyoung& Min, Sangyeon& Hong, Seung-Ug. Therapeutic Effects of Fermented Flax Seed Oil on NCNga Mice with Atopic Dermatitis-Like Skin Lesions. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1154074
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154074