Explicating the Pivotal Pathogenic, Diagnostic, and Therapeutic Biomarker Potentials of Myeloid-Derived Suppressor Cells in Glioblastoma
المؤلف
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-04
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Glioblastoma (GBM) is a malignant and aggressive central nervous tumor that originates from astrocytes.
These pathogenic astrocytes divide rapidly and are sustained by enormous network of blood vessels via which they receive requisite nutrients.
It well proven that GBM microenvironment is extremely infiltrated by myeloid-derived suppressor cells (MDSCs).
MDSCs are a heterogeneous cluster of immature myeloid progenitors.
They are key mediates in immune suppression as well as sustenance glioma growth, invasion, vascularization, and upsurge of regulatory T cells via different molecules.
MDSCs are often elevated in the peripheral blood of patients with GBM.
MDSCs in the peripheral blood as well as those infiltrating the GBM microenvironment correlated with poor prognosis.
Also, an upsurge in circulating MDSCs in the peripheral blood of patients with GBM was observed compared to benign and grade I/II glioma patients.
GBM patients with good prognosis presented with reduced MDSCs as well as augmented dendritic cells.
Almost all chemotherapeutic medication for GBM has shown no obvious improvement in overall survival in patients.
Nevertheless, low-dose chemotherapies were capable of suppressing the levels of MDSCs in GBM as well as multiple tumor models with metastatic to the brain.
Thus, MDSCs are potential diagnostic as well as therapeutic biomarkers for GBM patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Richard, Seidu A.. 2020. Explicating the Pivotal Pathogenic, Diagnostic, and Therapeutic Biomarker Potentials of Myeloid-Derived Suppressor Cells in Glioblastoma. Disease Markers،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1154114
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Richard, Seidu A.. Explicating the Pivotal Pathogenic, Diagnostic, and Therapeutic Biomarker Potentials of Myeloid-Derived Suppressor Cells in Glioblastoma. Disease Markers No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1154114
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Richard, Seidu A.. Explicating the Pivotal Pathogenic, Diagnostic, and Therapeutic Biomarker Potentials of Myeloid-Derived Suppressor Cells in Glioblastoma. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1154114
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154114
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر