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Explicating the Pivotal Pathogenic, Diagnostic, and Therapeutic Biomarker Potentials of Myeloid-Derived Suppressor Cells in Glioblastoma
Author
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-04
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Glioblastoma (GBM) is a malignant and aggressive central nervous tumor that originates from astrocytes.
These pathogenic astrocytes divide rapidly and are sustained by enormous network of blood vessels via which they receive requisite nutrients.
It well proven that GBM microenvironment is extremely infiltrated by myeloid-derived suppressor cells (MDSCs).
MDSCs are a heterogeneous cluster of immature myeloid progenitors.
They are key mediates in immune suppression as well as sustenance glioma growth, invasion, vascularization, and upsurge of regulatory T cells via different molecules.
MDSCs are often elevated in the peripheral blood of patients with GBM.
MDSCs in the peripheral blood as well as those infiltrating the GBM microenvironment correlated with poor prognosis.
Also, an upsurge in circulating MDSCs in the peripheral blood of patients with GBM was observed compared to benign and grade I/II glioma patients.
GBM patients with good prognosis presented with reduced MDSCs as well as augmented dendritic cells.
Almost all chemotherapeutic medication for GBM has shown no obvious improvement in overall survival in patients.
Nevertheless, low-dose chemotherapies were capable of suppressing the levels of MDSCs in GBM as well as multiple tumor models with metastatic to the brain.
Thus, MDSCs are potential diagnostic as well as therapeutic biomarkers for GBM patients.
American Psychological Association (APA)
Richard, Seidu A.. 2020. Explicating the Pivotal Pathogenic, Diagnostic, and Therapeutic Biomarker Potentials of Myeloid-Derived Suppressor Cells in Glioblastoma. Disease Markers،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1154114
Modern Language Association (MLA)
Richard, Seidu A.. Explicating the Pivotal Pathogenic, Diagnostic, and Therapeutic Biomarker Potentials of Myeloid-Derived Suppressor Cells in Glioblastoma. Disease Markers No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1154114
American Medical Association (AMA)
Richard, Seidu A.. Explicating the Pivotal Pathogenic, Diagnostic, and Therapeutic Biomarker Potentials of Myeloid-Derived Suppressor Cells in Glioblastoma. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1154114
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154114