TGFBR3 Polymorphisms (rs1805110 and rs7526590) Are Associated with Laboratory Biomarkers and Clinical Manifestations in Sickle Cell Anemia
المؤلفون المشاركون
Santiago, Rayra Pereira
Fonseca, Cleverson Alves
Figueiredo, Camylla Vilas Boas
Fiuza, Luciana Magalhães
Aleluia, Milena Magalhães
Oliveira, Rodrigo Mota
Carvalho, Suellen Pinheiro
Nascimento, Valma Maria Lopes
Rocha, Larissa Carneiro
Gonçalves, Marilda Souza
Yahouédéhou, Sétondji Cocou Modeste Alexandre
Guarda, Caroline Conceição
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-01
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Individuals with sickle cell anemia (SCA) present chronic anemia, hemolysis, an exacerbated inflammatory response, and heterogeneous clinical complications, which may be modulated by the transforming growth factor beta (TGF-β) pathway.
Thus, we aimed to investigate polymorphisms (rs1805110 and rs7526590) of the transforming growth factor beta receptor III gene (TGFBR3) with regard to laboratory biomarkers and clinical manifestations in individuals with SCA.
Hematological, biochemical, immunological, and genetic analyses were carried out, as well as serum endothelin-1 measurements.
The minor allele (A) of the TGFBR3 rs1805110 polymorphism was associated with increased hemoglobin, hematocrit, reticulocyte counts, total cholesterol, low-density lipoprotein, uric acid, and endothelin levels, as well as decreased platelet distribution width (PDW) and the occurrence of bone alterations.
The minor allele (T) of TGFBR3 rs7526590 was associated with increased red cell distribution width, PDW, alkaline phosphatase, aspartate aminotransferase, total and indirect bilirubin, and lactate dehydrogenase levels, as well as lower ferritin levels and the occurrence of leg ulcers.
Our data suggest that the minor allele (A) of TGFBR3 rs1805110 is associated with inflammation and bone alterations, while the minor allele (T) of TGFBR3 rs7526590 is related to hemolysis and the occurrence of leg ulcers.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Santiago, Rayra Pereira& Figueiredo, Camylla Vilas Boas& Fiuza, Luciana Magalhães& Yahouédéhou, Sétondji Cocou Modeste Alexandre& Oliveira, Rodrigo Mota& Aleluia, Milena Magalhães…[et al.]. 2020. TGFBR3 Polymorphisms (rs1805110 and rs7526590) Are Associated with Laboratory Biomarkers and Clinical Manifestations in Sickle Cell Anemia. Disease Markers،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1154152
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Santiago, Rayra Pereira…[et al.]. TGFBR3 Polymorphisms (rs1805110 and rs7526590) Are Associated with Laboratory Biomarkers and Clinical Manifestations in Sickle Cell Anemia. Disease Markers No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1154152
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Santiago, Rayra Pereira& Figueiredo, Camylla Vilas Boas& Fiuza, Luciana Magalhães& Yahouédéhou, Sétondji Cocou Modeste Alexandre& Oliveira, Rodrigo Mota& Aleluia, Milena Magalhães…[et al.]. TGFBR3 Polymorphisms (rs1805110 and rs7526590) Are Associated with Laboratory Biomarkers and Clinical Manifestations in Sickle Cell Anemia. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1154152
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154152
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر