TGFBR3 Polymorphisms (rs1805110 and rs7526590) Are Associated with Laboratory Biomarkers and Clinical Manifestations in Sickle Cell Anemia
Joint Authors
Santiago, Rayra Pereira
Fonseca, Cleverson Alves
Figueiredo, Camylla Vilas Boas
Fiuza, Luciana Magalhães
Aleluia, Milena Magalhães
Oliveira, Rodrigo Mota
Carvalho, Suellen Pinheiro
Nascimento, Valma Maria Lopes
Rocha, Larissa Carneiro
Gonçalves, Marilda Souza
Yahouédéhou, Sétondji Cocou Modeste Alexandre
Guarda, Caroline Conceição
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Individuals with sickle cell anemia (SCA) present chronic anemia, hemolysis, an exacerbated inflammatory response, and heterogeneous clinical complications, which may be modulated by the transforming growth factor beta (TGF-β) pathway.
Thus, we aimed to investigate polymorphisms (rs1805110 and rs7526590) of the transforming growth factor beta receptor III gene (TGFBR3) with regard to laboratory biomarkers and clinical manifestations in individuals with SCA.
Hematological, biochemical, immunological, and genetic analyses were carried out, as well as serum endothelin-1 measurements.
The minor allele (A) of the TGFBR3 rs1805110 polymorphism was associated with increased hemoglobin, hematocrit, reticulocyte counts, total cholesterol, low-density lipoprotein, uric acid, and endothelin levels, as well as decreased platelet distribution width (PDW) and the occurrence of bone alterations.
The minor allele (T) of TGFBR3 rs7526590 was associated with increased red cell distribution width, PDW, alkaline phosphatase, aspartate aminotransferase, total and indirect bilirubin, and lactate dehydrogenase levels, as well as lower ferritin levels and the occurrence of leg ulcers.
Our data suggest that the minor allele (A) of TGFBR3 rs1805110 is associated with inflammation and bone alterations, while the minor allele (T) of TGFBR3 rs7526590 is related to hemolysis and the occurrence of leg ulcers.
American Psychological Association (APA)
Santiago, Rayra Pereira& Figueiredo, Camylla Vilas Boas& Fiuza, Luciana Magalhães& Yahouédéhou, Sétondji Cocou Modeste Alexandre& Oliveira, Rodrigo Mota& Aleluia, Milena Magalhães…[et al.]. 2020. TGFBR3 Polymorphisms (rs1805110 and rs7526590) Are Associated with Laboratory Biomarkers and Clinical Manifestations in Sickle Cell Anemia. Disease Markers،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1154152
Modern Language Association (MLA)
Santiago, Rayra Pereira…[et al.]. TGFBR3 Polymorphisms (rs1805110 and rs7526590) Are Associated with Laboratory Biomarkers and Clinical Manifestations in Sickle Cell Anemia. Disease Markers No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1154152
American Medical Association (AMA)
Santiago, Rayra Pereira& Figueiredo, Camylla Vilas Boas& Fiuza, Luciana Magalhães& Yahouédéhou, Sétondji Cocou Modeste Alexandre& Oliveira, Rodrigo Mota& Aleluia, Milena Magalhães…[et al.]. TGFBR3 Polymorphisms (rs1805110 and rs7526590) Are Associated with Laboratory Biomarkers and Clinical Manifestations in Sickle Cell Anemia. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1154152
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154152