Association of Serum FAM19A5 with Cognitive Impairment in Vascular Dementia
المؤلفون المشاركون
Li, Juan
Li, Shoulin
Ma, Yihong
Zhu, Xiaohao
Xu, Suo
Zhu, Chunlin
Zhou, Wei
Song, Yihong
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-03
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Objective.
Family with sequence similarity 19 member A5 (FAM19A5), a novel chemokine-like peptide, is a secreted protein mainly expressed in the brain.
FAM19A5 was recently found to be involved in a variety of neurological diseases; however, its correlation with vascular dementia (VaD) remains unclear.
The aim of the study is to explore the association between serum FAM19A5 and cognitive impairment in subjects with VaD.
Method.
136 VaD subjects and 81 normal controls were recruited in the study.
Their demographic and clinical baseline data were collected on admission.
All subjects received Mini-Mental State Examination (MMSE) evaluation, which was used to test their cognitive functions.
A sandwich enzyme-linked immunosorbent assay (ELISA) was applied to detect the serum levels of FAM19A5.
Results.
No significant differences were found between the two groups regarding the demographic and clinical baseline data (p>0.05).
The serum FAM19A5 levels were significantly higher compared to normal controls (p<0.001).
The Spearman correlation analysis indicated that serum FAM19A5 levels and MMSE scores have a significant negative correlation in VaD patients (r=−0.414, <0.001).
Further multiple regression analysis indicated that serum FAM19A5 levels were independent risk predictors for cognitive functions in VaD (β=0.419, p=0.031).
Conclusion.
The serum FAM19A5 level of VaD patients is significantly increased, which may serve as a biomarker to predict cognitive function of VaD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Juan& Li, Shoulin& Song, Yihong& Zhou, Wei& Zhu, Xiaohao& Xu, Suo…[et al.]. 2020. Association of Serum FAM19A5 with Cognitive Impairment in Vascular Dementia. Disease Markers،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1154191
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Juan…[et al.]. Association of Serum FAM19A5 with Cognitive Impairment in Vascular Dementia. Disease Markers No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1154191
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Juan& Li, Shoulin& Song, Yihong& Zhou, Wei& Zhu, Xiaohao& Xu, Suo…[et al.]. Association of Serum FAM19A5 with Cognitive Impairment in Vascular Dementia. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1154191
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154191
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر