Association of Serum FAM19A5 with Cognitive Impairment in Vascular Dementia
Joint Authors
Li, Juan
Li, Shoulin
Ma, Yihong
Zhu, Xiaohao
Xu, Suo
Zhu, Chunlin
Zhou, Wei
Song, Yihong
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-03
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objective.
Family with sequence similarity 19 member A5 (FAM19A5), a novel chemokine-like peptide, is a secreted protein mainly expressed in the brain.
FAM19A5 was recently found to be involved in a variety of neurological diseases; however, its correlation with vascular dementia (VaD) remains unclear.
The aim of the study is to explore the association between serum FAM19A5 and cognitive impairment in subjects with VaD.
Method.
136 VaD subjects and 81 normal controls were recruited in the study.
Their demographic and clinical baseline data were collected on admission.
All subjects received Mini-Mental State Examination (MMSE) evaluation, which was used to test their cognitive functions.
A sandwich enzyme-linked immunosorbent assay (ELISA) was applied to detect the serum levels of FAM19A5.
Results.
No significant differences were found between the two groups regarding the demographic and clinical baseline data (p>0.05).
The serum FAM19A5 levels were significantly higher compared to normal controls (p<0.001).
The Spearman correlation analysis indicated that serum FAM19A5 levels and MMSE scores have a significant negative correlation in VaD patients (r=−0.414, <0.001).
Further multiple regression analysis indicated that serum FAM19A5 levels were independent risk predictors for cognitive functions in VaD (β=0.419, p=0.031).
Conclusion.
The serum FAM19A5 level of VaD patients is significantly increased, which may serve as a biomarker to predict cognitive function of VaD.
American Psychological Association (APA)
Li, Juan& Li, Shoulin& Song, Yihong& Zhou, Wei& Zhu, Xiaohao& Xu, Suo…[et al.]. 2020. Association of Serum FAM19A5 with Cognitive Impairment in Vascular Dementia. Disease Markers،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1154191
Modern Language Association (MLA)
Li, Juan…[et al.]. Association of Serum FAM19A5 with Cognitive Impairment in Vascular Dementia. Disease Markers No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1154191
American Medical Association (AMA)
Li, Juan& Li, Shoulin& Song, Yihong& Zhou, Wei& Zhu, Xiaohao& Xu, Suo…[et al.]. Association of Serum FAM19A5 with Cognitive Impairment in Vascular Dementia. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1154191
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154191