![](/images/graphics-bg.png)
Association of TLR-2 Gene Polymorphisms with the Risk of Periodontitis: A Meta-Analysis
المؤلفون المشاركون
Shan, Chao
Aisaiti, Abasijiang
Wu, Zhong Peng
Wang, Ting Ting
Zhao, Jin
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-08
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Background.
Periodontitis is a kind of chronic infectious disease, affecting the health of billions of people.
In recent years, a number of studies have shown that multiple immune gene polymorphisms are associated with the susceptibility to periodontitis, among which TLR-2 plays a critical role in periodontitis.
But most of the studies reported TLR-2 gene polymorphism and susceptibility to periodontitis are not consistent.
Therefore, we included all eligible studies in our study for further meta-analysis.
Methods.
We used electronic databases, including CNKI, PubMed, EMBASE, and Web of Science databases, and relevant research published through June, 2020.
Selecting studies involved case-control trials.
For all eligibility studies, odds ratios (ORs) and 95% confidence intervals (95% CI) are provided or can be calculated from the study data.
The size of the combined effect was calculated using STATA 15.0.
Results.
Our meta-analysis included 14 articles representing 18 case-control studies with a total of 3873 cases and 3438 control subjects.
Significant association was found between periodontitis and TLR-2 rs1898830 polymorphism under the allelic model (A allele vs.
G allele: p=0.014, OR=1.208, 95% CI: 1.039-1.406), recessive model (GG vs.
GA+AA: p=0.028, OR=0.755, 95% CI: 0.588-0.970), and codominant model (GG VS.
AA: p=0.014, OR=0.681, 95% CI: 0.501-0.925).
In subgroup analysis, TLR-2 rs5743708 polymorphism was associated with periodontitis risk in Asians under an allelic model (G allele vs.
A allele: p=0.017, OR=12.064, 95% CI: 1.570-92.688), dominant model (GA+AA vs.GG: p=0.016, OR=0.08, 95% CI: 0.010-0.620), and codominant model (GA VS.
GG: p=0.016, OR=1.026, 95% CI: 0.821-1.282).
Conclusion.
The TLR-2 rs1898830, rs5743708 polymorphism may be associated with susceptibility to periodontitis.
In the future, genome-wide approaches and large-scale, multiethnic case-control trials are still needed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shan, Chao& Aisaiti, Abasijiang& Wu, Zhong Peng& Wang, Ting Ting& Zhao, Jin. 2020. Association of TLR-2 Gene Polymorphisms with the Risk of Periodontitis: A Meta-Analysis. Disease Markers،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1154216
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shan, Chao…[et al.]. Association of TLR-2 Gene Polymorphisms with the Risk of Periodontitis: A Meta-Analysis. Disease Markers No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1154216
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shan, Chao& Aisaiti, Abasijiang& Wu, Zhong Peng& Wang, Ting Ting& Zhao, Jin. Association of TLR-2 Gene Polymorphisms with the Risk of Periodontitis: A Meta-Analysis. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1154216
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154216
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)