Association of TLR-2 Gene Polymorphisms with the Risk of Periodontitis: A Meta-Analysis

Abstract EN

Background.

Periodontitis is a kind of chronic infectious disease, affecting the health of billions of people.

In recent years, a number of studies have shown that multiple immune gene polymorphisms are associated with the susceptibility to periodontitis, among which TLR-2 plays a critical role in periodontitis.

But most of the studies reported TLR-2 gene polymorphism and susceptibility to periodontitis are not consistent.

Therefore, we included all eligible studies in our study for further meta-analysis.

Methods.

We used electronic databases, including CNKI, PubMed, EMBASE, and Web of Science databases, and relevant research published through June, 2020.

Selecting studies involved case-control trials.

For all eligibility studies, odds ratios (ORs) and 95% confidence intervals (95% CI) are provided or can be calculated from the study data.

The size of the combined effect was calculated using STATA 15.0.

Results.

Our meta-analysis included 14 articles representing 18 case-control studies with a total of 3873 cases and 3438 control subjects.

Significant association was found between periodontitis and TLR-2 rs1898830 polymorphism under the allelic model (A allele vs.

G allele: p=0.014, OR=1.208, 95% CI: 1.039-1.406), recessive model (GG vs.

GA+AA: p=0.028, OR=0.755, 95% CI: 0.588-0.970), and codominant model (GG VS.

AA: p=0.014, OR=0.681, 95% CI: 0.501-0.925).

In subgroup analysis, TLR-2 rs5743708 polymorphism was associated with periodontitis risk in Asians under an allelic model (G allele vs.

A allele: p=0.017, OR=12.064, 95% CI: 1.570-92.688), dominant model (GA+AA vs.GG: p=0.016, OR=0.08, 95% CI: 0.010-0.620), and codominant model (GA VS.

GG: p=0.016, OR=1.026, 95% CI: 0.821-1.282).

Conclusion.

The TLR-2 rs1898830, rs5743708 polymorphism may be associated with susceptibility to periodontitis.

In the future, genome-wide approaches and large-scale, multiethnic case-control trials are still needed.