miR-1291 Functions as a Potential Serum Biomarker for Bullous Pemphigoid
المؤلفون المشاركون
Chen, Hong-Duo
Qi, Ruiqun
Qiu, Li
Zhang, Liming
Xiao, Ting
Gao, X.-H.
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-01-11
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Bullous pemphigoid (BP) is a common T helper 2- (Th2-) dominated autoimmune blistering skin disease with significant mortality.
MicroRNAs (miRNAs), which are endogenous noncoding RNA molecules, have been reported to be potential biomarkers for some autoimmune diseases; however, to date, there exist no reports on serum expression profiles of miRNAs in BP patients.
Methods.
A RNA quantitative PCR- (qPCR-) based array was conducted on sera from 20 active BP patients and 20 healthy controls for screening of miRNAs.
Significantly dysregulated miRNAs were validated with use of qPCR as performed on sera samples of 45 active BP patients and 60 healthy controls.
Serum CCL17, anti-BP180, and anti-BP230 levels were measured with use of ELISA.
Results.
Relative baseline expression levels of serum miR-1291 were significantly upregulated in the 45 BP patients as compared with the 60 healthy controls (P<0.001) and significantly decreased in the disease control stage (n=13, P=0.006).
In addition, these baseline miR-1291 levels showed a significant positive correlation with the baseline levels of serum CCL17 (P<0.001) and anti-BP180 (n=38, P=0.024).
Like that observed for miR-1291, baseline levels of serum CCL17 were also significantly elevated in the 45 BP patients compared with the 60 healthy controls (P<0.001) and significantly decreased in the disease control stage (n=13, P=0.002).
However, for anti-BP180, baseline serum levels were significantly elevated in only 38 of the 45 BP patients and significantly decreased in the disease control stage (n=10, P=0.004).
Conclusions.
Relative expression levels of serum miR-1291 can reflect disease activity of BP.
miR-1291 may function as an important new serum biomarker for BP.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Qiu, Li& Zhang, Liming& Qi, Ruiqun& Gao, X.-H.& Chen, Hong-Duo& Xiao, Ting. 2020. miR-1291 Functions as a Potential Serum Biomarker for Bullous Pemphigoid. Disease Markers،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1154224
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Qiu, Li…[et al.]. miR-1291 Functions as a Potential Serum Biomarker for Bullous Pemphigoid. Disease Markers No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1154224
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Qiu, Li& Zhang, Liming& Qi, Ruiqun& Gao, X.-H.& Chen, Hong-Duo& Xiao, Ting. miR-1291 Functions as a Potential Serum Biomarker for Bullous Pemphigoid. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1154224
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154224
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر