miR-1291 Functions as a Potential Serum Biomarker for Bullous Pemphigoid

Joint Authors

Chen, Hong-Duo
Qi, Ruiqun
Qiu, Li
Zhang, Liming
Xiao, Ting
Gao, X.-H.

Source

Disease Markers

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-01-11

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Diseases

Abstract EN

Background.

Bullous pemphigoid (BP) is a common T helper 2- (Th2-) dominated autoimmune blistering skin disease with significant mortality.

MicroRNAs (miRNAs), which are endogenous noncoding RNA molecules, have been reported to be potential biomarkers for some autoimmune diseases; however, to date, there exist no reports on serum expression profiles of miRNAs in BP patients.

Methods.

A RNA quantitative PCR- (qPCR-) based array was conducted on sera from 20 active BP patients and 20 healthy controls for screening of miRNAs.

Significantly dysregulated miRNAs were validated with use of qPCR as performed on sera samples of 45 active BP patients and 60 healthy controls.

Serum CCL17, anti-BP180, and anti-BP230 levels were measured with use of ELISA.

Results.

Relative baseline expression levels of serum miR-1291 were significantly upregulated in the 45 BP patients as compared with the 60 healthy controls (P<0.001) and significantly decreased in the disease control stage (n=13, P=0.006).

In addition, these baseline miR-1291 levels showed a significant positive correlation with the baseline levels of serum CCL17 (P<0.001) and anti-BP180 (n=38, P=0.024).

Like that observed for miR-1291, baseline levels of serum CCL17 were also significantly elevated in the 45 BP patients compared with the 60 healthy controls (P<0.001) and significantly decreased in the disease control stage (n=13, P=0.002).

However, for anti-BP180, baseline serum levels were significantly elevated in only 38 of the 45 BP patients and significantly decreased in the disease control stage (n=10, P=0.004).

Conclusions.

Relative expression levels of serum miR-1291 can reflect disease activity of BP.

miR-1291 may function as an important new serum biomarker for BP.

American Psychological Association (APA)

Qiu, Li& Zhang, Liming& Qi, Ruiqun& Gao, X.-H.& Chen, Hong-Duo& Xiao, Ting. 2020. miR-1291 Functions as a Potential Serum Biomarker for Bullous Pemphigoid. Disease Markers،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1154224

Modern Language Association (MLA)

Qiu, Li…[et al.]. miR-1291 Functions as a Potential Serum Biomarker for Bullous Pemphigoid. Disease Markers No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1154224

American Medical Association (AMA)

Qiu, Li& Zhang, Liming& Qi, Ruiqun& Gao, X.-H.& Chen, Hong-Duo& Xiao, Ting. miR-1291 Functions as a Potential Serum Biomarker for Bullous Pemphigoid. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1154224

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1154224