Antidepressant-Like Effect of Selected Egyptian Cultivars of Flaxseed Oil on a Rodent Model of Postpartum Depression
المؤلفون المشاركون
Abdel Sattar, Essam
Ezzat, Shahira M.
El Tanbouly, Nebal
El Sayed, Abeer Mohamed
Ali, Zeinab Y.
Abdel Wahab, Samia
El Gayed, Sabah H.
El Senousy, Amira Safwat
Choucry, Mouchira A.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-11-29
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Flaxseed (Linum usitatissimum L.) is a multipurpose crop with health promoting potential.
This study was undertaken to investigate the fatty acid profile and yield of fixed oil of six Egyptian flaxseed cultivars.
The selected cultivars with the highest content of polyunsaturated fatty acids (PUFAs) (G9 and G10) were assessed for their antidepressant-like effect in rat model of postpartum depression (PPD) induced by hormone-simulated pregnancy followed by hormone withdrawal and compared to fluoxetine.
As compared to control group, administration of G9 and G10 (270 mg/kg/day, p.o) for two weeks during the postpartum period can alleviate anxiety and depressive-like behaviors and biochemical changes in PPD-induced rats.
This was confirmed by evaluation of anxiety-like behaviors (elevated plus maze, open field test, and forced swim test tests), in addition to biochemical analysis (brain monoamine oxidase-A, corticosterone level, proinflammatory cytokines, and hippocampal redox state).
In conclusion, flaxseed oil of Egyptian cultivars G9 and G10 exhibited significant antidepressant-like effect in rat model of PPD without affecting locomotor activity.
At the treatment doses, the antidepressant-like activity of Giza 9 oil is comparable to fluoxetine.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
El Tanbouly, Nebal& El Sayed, Abeer Mohamed& Ali, Zeinab Y.& Abdel Wahab, Samia& El Gayed, Sabah H.& Ezzat, Shahira M.…[et al.]. 2017. Antidepressant-Like Effect of Selected Egyptian Cultivars of Flaxseed Oil on a Rodent Model of Postpartum Depression. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1154289
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
El Tanbouly, Nebal…[et al.]. Antidepressant-Like Effect of Selected Egyptian Cultivars of Flaxseed Oil on a Rodent Model of Postpartum Depression. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1154289
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
El Tanbouly, Nebal& El Sayed, Abeer Mohamed& Ali, Zeinab Y.& Abdel Wahab, Samia& El Gayed, Sabah H.& Ezzat, Shahira M.…[et al.]. Antidepressant-Like Effect of Selected Egyptian Cultivars of Flaxseed Oil on a Rodent Model of Postpartum Depression. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1154289
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154289
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر