Antidepressant-Like Effect of Selected Egyptian Cultivars of Flaxseed Oil on a Rodent Model of Postpartum Depression
Joint Authors
Abdel Sattar, Essam
Ezzat, Shahira M.
El Tanbouly, Nebal
El Sayed, Abeer Mohamed
Ali, Zeinab Y.
Abdel Wahab, Samia
El Gayed, Sabah H.
El Senousy, Amira Safwat
Choucry, Mouchira A.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-29
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Flaxseed (Linum usitatissimum L.) is a multipurpose crop with health promoting potential.
This study was undertaken to investigate the fatty acid profile and yield of fixed oil of six Egyptian flaxseed cultivars.
The selected cultivars with the highest content of polyunsaturated fatty acids (PUFAs) (G9 and G10) were assessed for their antidepressant-like effect in rat model of postpartum depression (PPD) induced by hormone-simulated pregnancy followed by hormone withdrawal and compared to fluoxetine.
As compared to control group, administration of G9 and G10 (270 mg/kg/day, p.o) for two weeks during the postpartum period can alleviate anxiety and depressive-like behaviors and biochemical changes in PPD-induced rats.
This was confirmed by evaluation of anxiety-like behaviors (elevated plus maze, open field test, and forced swim test tests), in addition to biochemical analysis (brain monoamine oxidase-A, corticosterone level, proinflammatory cytokines, and hippocampal redox state).
In conclusion, flaxseed oil of Egyptian cultivars G9 and G10 exhibited significant antidepressant-like effect in rat model of PPD without affecting locomotor activity.
At the treatment doses, the antidepressant-like activity of Giza 9 oil is comparable to fluoxetine.
American Psychological Association (APA)
El Tanbouly, Nebal& El Sayed, Abeer Mohamed& Ali, Zeinab Y.& Abdel Wahab, Samia& El Gayed, Sabah H.& Ezzat, Shahira M.…[et al.]. 2017. Antidepressant-Like Effect of Selected Egyptian Cultivars of Flaxseed Oil on a Rodent Model of Postpartum Depression. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1154289
Modern Language Association (MLA)
El Tanbouly, Nebal…[et al.]. Antidepressant-Like Effect of Selected Egyptian Cultivars of Flaxseed Oil on a Rodent Model of Postpartum Depression. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1154289
American Medical Association (AMA)
El Tanbouly, Nebal& El Sayed, Abeer Mohamed& Ali, Zeinab Y.& Abdel Wahab, Samia& El Gayed, Sabah H.& Ezzat, Shahira M.…[et al.]. Antidepressant-Like Effect of Selected Egyptian Cultivars of Flaxseed Oil on a Rodent Model of Postpartum Depression. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1154289
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154289