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Compounds from Cynomorium songaricum with Estrogenic and Androgenic Activities Suppress the OestrogenAndrogen-Induced BPH Process
المؤلفون المشاركون
Zhu, Yan
Chang, Yanxu
Gao, Xiu-Mei
Wang, Hong
Wang, Xueni
Tao, Rui
Yang, Jing
Miao, Lin
Wang, Yu
Munyangaju, Jose Edouard
Wichai, Nuttapong
Liu, Erwei
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-15
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Objective.
To investigate the phytoestrogenic and phytoandrogenic activities of compounds isolated from CS and uncover the role of CS in prevention of oestrogen/androgen-induced BPH.
Methods.
Cells were treated with CS compounds, and immunofluorescence assay was performed to detect the nuclear translocation of ERα or AR in MCF-7 or LNCaP cells; luciferase reporter assay was performed to detect ERs or AR transcriptional activity in HeLa or AD293 cells; MTT assay was performed to detect the cell proliferation of MCF-7 or LNCaP cells.
Oestrogen/androgen-induced BPH model was established in rat and the anti-BPH, anti-estrogenic, and anti-androgenic activities of CS in vivo were further investigated.
Results.
The nuclear translocation of ERα was stimulated by nine CS compounds, three of which also stimulated AR translocation.
The transcriptional activities of ERα and ERβ were induced by five compounds, within which only ECG induced AR transcriptional activity as well.
Besides, ECG stimulated the proliferation of both MCF-7 cells and LNCaP cells.
CS extract suppressed oestrogen/androgen-induced BPH progress in vivo by downregulation of E2 and T level in serum and alteration of the expressions of ERα, ERβ, and AR in the prostate.
Conclusion.
Our data demonstrates that compounds from CS exhibit phytoestrogenic and phytoandrogenic activities, which may contribute to inhibiting the oestrogen/androgen-induced BPH development.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Xueni& Tao, Rui& Yang, Jing& Miao, Lin& Wang, Yu& Munyangaju, Jose Edouard…[et al.]. 2017. Compounds from Cynomorium songaricum with Estrogenic and Androgenic Activities Suppress the OestrogenAndrogen-Induced BPH Process. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1154320
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Xueni…[et al.]. Compounds from Cynomorium songaricum with Estrogenic and Androgenic Activities Suppress the OestrogenAndrogen-Induced BPH Process. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1154320
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Xueni& Tao, Rui& Yang, Jing& Miao, Lin& Wang, Yu& Munyangaju, Jose Edouard…[et al.]. Compounds from Cynomorium songaricum with Estrogenic and Androgenic Activities Suppress the OestrogenAndrogen-Induced BPH Process. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1154320
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154320
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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