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Compounds from Cynomorium songaricum with Estrogenic and Androgenic Activities Suppress the OestrogenAndrogen-Induced BPH Process
Joint Authors
Zhu, Yan
Chang, Yanxu
Gao, Xiu-Mei
Wang, Hong
Wang, Xueni
Tao, Rui
Yang, Jing
Miao, Lin
Wang, Yu
Munyangaju, Jose Edouard
Wichai, Nuttapong
Liu, Erwei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-15
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Objective.
To investigate the phytoestrogenic and phytoandrogenic activities of compounds isolated from CS and uncover the role of CS in prevention of oestrogen/androgen-induced BPH.
Methods.
Cells were treated with CS compounds, and immunofluorescence assay was performed to detect the nuclear translocation of ERα or AR in MCF-7 or LNCaP cells; luciferase reporter assay was performed to detect ERs or AR transcriptional activity in HeLa or AD293 cells; MTT assay was performed to detect the cell proliferation of MCF-7 or LNCaP cells.
Oestrogen/androgen-induced BPH model was established in rat and the anti-BPH, anti-estrogenic, and anti-androgenic activities of CS in vivo were further investigated.
Results.
The nuclear translocation of ERα was stimulated by nine CS compounds, three of which also stimulated AR translocation.
The transcriptional activities of ERα and ERβ were induced by five compounds, within which only ECG induced AR transcriptional activity as well.
Besides, ECG stimulated the proliferation of both MCF-7 cells and LNCaP cells.
CS extract suppressed oestrogen/androgen-induced BPH progress in vivo by downregulation of E2 and T level in serum and alteration of the expressions of ERα, ERβ, and AR in the prostate.
Conclusion.
Our data demonstrates that compounds from CS exhibit phytoestrogenic and phytoandrogenic activities, which may contribute to inhibiting the oestrogen/androgen-induced BPH development.
American Psychological Association (APA)
Wang, Xueni& Tao, Rui& Yang, Jing& Miao, Lin& Wang, Yu& Munyangaju, Jose Edouard…[et al.]. 2017. Compounds from Cynomorium songaricum with Estrogenic and Androgenic Activities Suppress the OestrogenAndrogen-Induced BPH Process. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1154320
Modern Language Association (MLA)
Wang, Xueni…[et al.]. Compounds from Cynomorium songaricum with Estrogenic and Androgenic Activities Suppress the OestrogenAndrogen-Induced BPH Process. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1154320
American Medical Association (AMA)
Wang, Xueni& Tao, Rui& Yang, Jing& Miao, Lin& Wang, Yu& Munyangaju, Jose Edouard…[et al.]. Compounds from Cynomorium songaricum with Estrogenic and Androgenic Activities Suppress the OestrogenAndrogen-Induced BPH Process. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1154320
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154320