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Scutellaria baicalensis Attenuates Airway Remodeling via PI3KAktNF-κB Pathway in Cigarette Smoke Mediated-COPD Rats Model
المؤلفون المشاركون
Wei, Ying
Xu, Fei
Lin, Jinpei
Li, Lulu
Dong, Jingcheng
Li, Qiuping
Cui, Wenqiang
Kong, Qing
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-13
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background.
Scutellaria baicalensis (SB) is commonly used in traditional Chinese medicine for chronic inflammatory diseases.
This study aims to investigate the effects of the early intervention with SB on airway remodeling in a well-established rat model of COPD induced by cigarette smoking.
Methods.
COPD model in Sprague Dawley (SD) rats were established by exposing them to smoke for 6 days/week, for 12 weeks, 24 weeks, or 36 weeks.
Meanwhile, rats were randomly divided into normal control group, model group, Budesonide (BUD) group, and the SB (low, middle, and high) dose groups with 8 rats in each group and 3 stages (12 weeks, 24 weeks, and 36 weeks).
After treatment, the pulmonary function was evaluated by BUXCO system and the morphology changes of the lungs were observed with HE and Masson staining.
The serum IL-6, IL-8, and IL-10 and TNF-α, TGF-beta (TGF-β1), MMP-2, MMP-9, and TIMP-1 levels in BALF were detected by ELISA-kit assay.
The protein expression levels of AKT and NF-κB (p65) were determined by western blot (WB).
Results.
The oral of SB significantly improved pulmonary function (PF) and ameliorated the pathological damage and attenuated inflammatory cytokines infiltration into the lungs.
Meanwhile, the levels of TGF-β, MMP-2, MMP-9, and TIMP-1 were partially significantly decreased.
The levels of PI3K/AKT/NF-κB pathway were also markedly suppressed by SB.
Conclusions.
SB could significantly improve the condition of airway remodeling by inhibiting airway inflammation and partially quenching TGF-β and MMPs via PI3K/AKT/NF-κB pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Fei& Lin, Jinpei& Cui, Wenqiang& Kong, Qing& Li, Qiuping& Li, Lulu…[et al.]. 2018. Scutellaria baicalensis Attenuates Airway Remodeling via PI3KAktNF-κB Pathway in Cigarette Smoke Mediated-COPD Rats Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1154345
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Fei…[et al.]. Scutellaria baicalensis Attenuates Airway Remodeling via PI3KAktNF-κB Pathway in Cigarette Smoke Mediated-COPD Rats Model. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1154345
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Fei& Lin, Jinpei& Cui, Wenqiang& Kong, Qing& Li, Qiuping& Li, Lulu…[et al.]. Scutellaria baicalensis Attenuates Airway Remodeling via PI3KAktNF-κB Pathway in Cigarette Smoke Mediated-COPD Rats Model. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1154345
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154345
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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