Scutellaria baicalensis Attenuates Airway Remodeling via PI3KAktNF-κB Pathway in Cigarette Smoke Mediated-COPD Rats Model
Joint Authors
Wei, Ying
Xu, Fei
Lin, Jinpei
Li, Lulu
Dong, Jingcheng
Li, Qiuping
Cui, Wenqiang
Kong, Qing
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-13
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
Scutellaria baicalensis (SB) is commonly used in traditional Chinese medicine for chronic inflammatory diseases.
This study aims to investigate the effects of the early intervention with SB on airway remodeling in a well-established rat model of COPD induced by cigarette smoking.
Methods.
COPD model in Sprague Dawley (SD) rats were established by exposing them to smoke for 6 days/week, for 12 weeks, 24 weeks, or 36 weeks.
Meanwhile, rats were randomly divided into normal control group, model group, Budesonide (BUD) group, and the SB (low, middle, and high) dose groups with 8 rats in each group and 3 stages (12 weeks, 24 weeks, and 36 weeks).
After treatment, the pulmonary function was evaluated by BUXCO system and the morphology changes of the lungs were observed with HE and Masson staining.
The serum IL-6, IL-8, and IL-10 and TNF-α, TGF-beta (TGF-β1), MMP-2, MMP-9, and TIMP-1 levels in BALF were detected by ELISA-kit assay.
The protein expression levels of AKT and NF-κB (p65) were determined by western blot (WB).
Results.
The oral of SB significantly improved pulmonary function (PF) and ameliorated the pathological damage and attenuated inflammatory cytokines infiltration into the lungs.
Meanwhile, the levels of TGF-β, MMP-2, MMP-9, and TIMP-1 were partially significantly decreased.
The levels of PI3K/AKT/NF-κB pathway were also markedly suppressed by SB.
Conclusions.
SB could significantly improve the condition of airway remodeling by inhibiting airway inflammation and partially quenching TGF-β and MMPs via PI3K/AKT/NF-κB pathway.
American Psychological Association (APA)
Xu, Fei& Lin, Jinpei& Cui, Wenqiang& Kong, Qing& Li, Qiuping& Li, Lulu…[et al.]. 2018. Scutellaria baicalensis Attenuates Airway Remodeling via PI3KAktNF-κB Pathway in Cigarette Smoke Mediated-COPD Rats Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1154345
Modern Language Association (MLA)
Xu, Fei…[et al.]. Scutellaria baicalensis Attenuates Airway Remodeling via PI3KAktNF-κB Pathway in Cigarette Smoke Mediated-COPD Rats Model. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1154345
American Medical Association (AMA)
Xu, Fei& Lin, Jinpei& Cui, Wenqiang& Kong, Qing& Li, Qiuping& Li, Lulu…[et al.]. Scutellaria baicalensis Attenuates Airway Remodeling via PI3KAktNF-κB Pathway in Cigarette Smoke Mediated-COPD Rats Model. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1154345
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154345