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MMP-Inhibitory Effects of Flavonoid Glycosides from Edible Medicinal Halophyte Limonium tetragonum
المؤلفون المشاركون
Karadeniz, Fatih
Nam, Ki-Ho
Seo, Youngwan
Kong, Chang-Suk
Bae, Min Joo
Oh, Jung Hwan
Yu, Ga Hyun
Jang, Mi-Soon
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-20
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Limonium tetragonum has been well-known for its antioxidative properties as a halophyte.
This study investigated the antimetastasis effect of solvent-partitioned L.
tetragonum extracts (LTEs) and isolated compounds on HT1080 mouse melanoma cell model with a focus on matrix metalloproteinase (MMP) activity and TIMP and MAPK pathways.
Upregulation and stimulation of MMPs result in elevated degradation of extracellular matrix which is part of several complications such as metastasis, cirrhosis, and arthritis.
The anti-MMP capacity of LTEs was confirmed by their MMP-inhibitory effects, regulation of MMP and TIMP expression, and suppression of MAPK pathway.
Among all tested LTEs, 85% aq.
MeOH and n-BuOH were found to be most active fractions which later yielded two known flavonoid glycosides, myricetin 3-galactoside and quercetin 3-o-beta-galactopyranoside.
Anti-MMP potential of the compounds was confirmed by their ability to regulate MMP expression through inhibited MAPK pathway activation.
These results suggested that L.
tetragonum might serve as a potential source of bioactive substances with effective anti-MMP properties.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bae, Min Joo& Karadeniz, Fatih& Oh, Jung Hwan& Yu, Ga Hyun& Jang, Mi-Soon& Nam, Ki-Ho…[et al.]. 2017. MMP-Inhibitory Effects of Flavonoid Glycosides from Edible Medicinal Halophyte Limonium tetragonum. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1154378
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bae, Min Joo…[et al.]. MMP-Inhibitory Effects of Flavonoid Glycosides from Edible Medicinal Halophyte Limonium tetragonum. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1154378
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bae, Min Joo& Karadeniz, Fatih& Oh, Jung Hwan& Yu, Ga Hyun& Jang, Mi-Soon& Nam, Ki-Ho…[et al.]. MMP-Inhibitory Effects of Flavonoid Glycosides from Edible Medicinal Halophyte Limonium tetragonum. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1154378
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154378
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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