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MMP-Inhibitory Effects of Flavonoid Glycosides from Edible Medicinal Halophyte Limonium tetragonum
Joint Authors
Karadeniz, Fatih
Nam, Ki-Ho
Seo, Youngwan
Kong, Chang-Suk
Bae, Min Joo
Oh, Jung Hwan
Yu, Ga Hyun
Jang, Mi-Soon
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Limonium tetragonum has been well-known for its antioxidative properties as a halophyte.
This study investigated the antimetastasis effect of solvent-partitioned L.
tetragonum extracts (LTEs) and isolated compounds on HT1080 mouse melanoma cell model with a focus on matrix metalloproteinase (MMP) activity and TIMP and MAPK pathways.
Upregulation and stimulation of MMPs result in elevated degradation of extracellular matrix which is part of several complications such as metastasis, cirrhosis, and arthritis.
The anti-MMP capacity of LTEs was confirmed by their MMP-inhibitory effects, regulation of MMP and TIMP expression, and suppression of MAPK pathway.
Among all tested LTEs, 85% aq.
MeOH and n-BuOH were found to be most active fractions which later yielded two known flavonoid glycosides, myricetin 3-galactoside and quercetin 3-o-beta-galactopyranoside.
Anti-MMP potential of the compounds was confirmed by their ability to regulate MMP expression through inhibited MAPK pathway activation.
These results suggested that L.
tetragonum might serve as a potential source of bioactive substances with effective anti-MMP properties.
American Psychological Association (APA)
Bae, Min Joo& Karadeniz, Fatih& Oh, Jung Hwan& Yu, Ga Hyun& Jang, Mi-Soon& Nam, Ki-Ho…[et al.]. 2017. MMP-Inhibitory Effects of Flavonoid Glycosides from Edible Medicinal Halophyte Limonium tetragonum. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1154378
Modern Language Association (MLA)
Bae, Min Joo…[et al.]. MMP-Inhibitory Effects of Flavonoid Glycosides from Edible Medicinal Halophyte Limonium tetragonum. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1154378
American Medical Association (AMA)
Bae, Min Joo& Karadeniz, Fatih& Oh, Jung Hwan& Yu, Ga Hyun& Jang, Mi-Soon& Nam, Ki-Ho…[et al.]. MMP-Inhibitory Effects of Flavonoid Glycosides from Edible Medicinal Halophyte Limonium tetragonum. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1154378
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154378