Quercetin Potentiates the NGF-Induced Effects in Cultured PC 12 Cells: Identification by HerboChips Showing a Binding with NGF
المؤلفون المشاركون
Chan, Gallant K. L.
Hu, Winnie W. H.
Zheng, Zoey X.
Huang, M.
Lin, Yan X. Y.
Wang, Caroline Y.
Gong, Amy G. W.
Yang, X. Y.
Dong, Tina Ting-Xia
Tsim, Karl Wah-Keung
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-28
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Dementia is a persistent disorder of the mental processes and is strongly related to depression.
However, the performance of current antidepression medicine is far from satisfactory.
Herbal extract provides an excellent source to identify compounds for possible drug development against depression.
Here, HerboChips were employed to search herbal compounds that could bind nerve growth factor (NGF).
By screening over 500 types of herbal extracts, the water extract of Ginkgo Folium, the leaf of Ginkgo biloba, showed a strong binding to NGF.
The herbal fractions showing NGF binding were further isolated and enriched.
By using LC-MS/MS analysis, one of the NGF binding fractions was enriched, which was further identified as quercetin, a major flavonoid in Ginkgo Folium.
Quercetin, similar to Ginkgo Folium extract, could enhance the effect of NGF in cultured PC 12 cells, including potentiation of neurite outgrowth and phosphorylation of Erk-1/2.
This is the first report of discovering an NGF binding compound by using HerboChips from herbal extracts, which could be further developed for antidepression application.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chan, Gallant K. L.& Hu, Winnie W. H.& Zheng, Zoey X.& Huang, M.& Lin, Yan X. Y.& Wang, Caroline Y.…[et al.]. 2018. Quercetin Potentiates the NGF-Induced Effects in Cultured PC 12 Cells: Identification by HerboChips Showing a Binding with NGF. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1154407
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chan, Gallant K. L.…[et al.]. Quercetin Potentiates the NGF-Induced Effects in Cultured PC 12 Cells: Identification by HerboChips Showing a Binding with NGF. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1154407
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chan, Gallant K. L.& Hu, Winnie W. H.& Zheng, Zoey X.& Huang, M.& Lin, Yan X. Y.& Wang, Caroline Y.…[et al.]. Quercetin Potentiates the NGF-Induced Effects in Cultured PC 12 Cells: Identification by HerboChips Showing a Binding with NGF. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1154407
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154407
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر