Quercetin Potentiates the NGF-Induced Effects in Cultured PC 12 Cells: Identification by HerboChips Showing a Binding with NGF
Joint Authors
Chan, Gallant K. L.
Hu, Winnie W. H.
Zheng, Zoey X.
Huang, M.
Lin, Yan X. Y.
Wang, Caroline Y.
Gong, Amy G. W.
Yang, X. Y.
Dong, Tina Ting-Xia
Tsim, Karl Wah-Keung
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Dementia is a persistent disorder of the mental processes and is strongly related to depression.
However, the performance of current antidepression medicine is far from satisfactory.
Herbal extract provides an excellent source to identify compounds for possible drug development against depression.
Here, HerboChips were employed to search herbal compounds that could bind nerve growth factor (NGF).
By screening over 500 types of herbal extracts, the water extract of Ginkgo Folium, the leaf of Ginkgo biloba, showed a strong binding to NGF.
The herbal fractions showing NGF binding were further isolated and enriched.
By using LC-MS/MS analysis, one of the NGF binding fractions was enriched, which was further identified as quercetin, a major flavonoid in Ginkgo Folium.
Quercetin, similar to Ginkgo Folium extract, could enhance the effect of NGF in cultured PC 12 cells, including potentiation of neurite outgrowth and phosphorylation of Erk-1/2.
This is the first report of discovering an NGF binding compound by using HerboChips from herbal extracts, which could be further developed for antidepression application.
American Psychological Association (APA)
Chan, Gallant K. L.& Hu, Winnie W. H.& Zheng, Zoey X.& Huang, M.& Lin, Yan X. Y.& Wang, Caroline Y.…[et al.]. 2018. Quercetin Potentiates the NGF-Induced Effects in Cultured PC 12 Cells: Identification by HerboChips Showing a Binding with NGF. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1154407
Modern Language Association (MLA)
Chan, Gallant K. L.…[et al.]. Quercetin Potentiates the NGF-Induced Effects in Cultured PC 12 Cells: Identification by HerboChips Showing a Binding with NGF. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1154407
American Medical Association (AMA)
Chan, Gallant K. L.& Hu, Winnie W. H.& Zheng, Zoey X.& Huang, M.& Lin, Yan X. Y.& Wang, Caroline Y.…[et al.]. Quercetin Potentiates the NGF-Induced Effects in Cultured PC 12 Cells: Identification by HerboChips Showing a Binding with NGF. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1154407
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154407