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Potential Protective Effects of Bioactive Constituents from Chinese Propolis against Acute Oxidative Stress Induced by Hydrogen Peroxide in Cardiac H9c2 Cells
المؤلفون المشاركون
Wang, Kai
Chen, Yi-Fan
Sun, Li-Ping
Xu, Xiang
Ge, Miaomiao
Hu, Fuliang
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-27
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Chinese propolis (CP) is known as a health food but its beneficial effects in protecting cardiomyocytes remain elusive.
Here, we investigated the effects of CP and its active compounds on hydrogen peroxide (H2O2) induced rats cardiomyocytes (H9c2) oxidative injury.
Cell viability decreases induced by H2O2 were mitigated by different CP extracts using various solvents.
From these active fractions, six active compounds were separated and identified.
Among tested isolated compound, the cytoprotective activities of three caffeates, caffeic acid phenethyl ester (CAPE), benzyl caffeate (BZC), and cinnamyl caffeate (CNC), exerted stronger effects than chrysin, pinobanksin, and 3,4-dimethoxycinnamic acid (DMCA).
These three caffeates also increased H9c2 cellular antioxidant potential, decreased intracellular calcium ion (Ca2+i) level, and prevented cell apoptosis.
Overall, the cardiovascular protective effects of the CP might be attributed to its caffeates constituents (CAPE, BZC, and CNC) and provide evidence for its usage in complementary and alternative medicine.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sun, Li-Ping& Wang, Kai& Xu, Xiang& Ge, Miaomiao& Chen, Yi-Fan& Hu, Fuliang. 2017. Potential Protective Effects of Bioactive Constituents from Chinese Propolis against Acute Oxidative Stress Induced by Hydrogen Peroxide in Cardiac H9c2 Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1154434
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sun, Li-Ping…[et al.]. Potential Protective Effects of Bioactive Constituents from Chinese Propolis against Acute Oxidative Stress Induced by Hydrogen Peroxide in Cardiac H9c2 Cells. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1154434
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sun, Li-Ping& Wang, Kai& Xu, Xiang& Ge, Miaomiao& Chen, Yi-Fan& Hu, Fuliang. Potential Protective Effects of Bioactive Constituents from Chinese Propolis against Acute Oxidative Stress Induced by Hydrogen Peroxide in Cardiac H9c2 Cells. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1154434
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154434
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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