Potential Protective Effects of Bioactive Constituents from Chinese Propolis against Acute Oxidative Stress Induced by Hydrogen Peroxide in Cardiac H9c2 Cells
Joint Authors
Wang, Kai
Chen, Yi-Fan
Sun, Li-Ping
Xu, Xiang
Ge, Miaomiao
Hu, Fuliang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Chinese propolis (CP) is known as a health food but its beneficial effects in protecting cardiomyocytes remain elusive.
Here, we investigated the effects of CP and its active compounds on hydrogen peroxide (H2O2) induced rats cardiomyocytes (H9c2) oxidative injury.
Cell viability decreases induced by H2O2 were mitigated by different CP extracts using various solvents.
From these active fractions, six active compounds were separated and identified.
Among tested isolated compound, the cytoprotective activities of three caffeates, caffeic acid phenethyl ester (CAPE), benzyl caffeate (BZC), and cinnamyl caffeate (CNC), exerted stronger effects than chrysin, pinobanksin, and 3,4-dimethoxycinnamic acid (DMCA).
These three caffeates also increased H9c2 cellular antioxidant potential, decreased intracellular calcium ion (Ca2+i) level, and prevented cell apoptosis.
Overall, the cardiovascular protective effects of the CP might be attributed to its caffeates constituents (CAPE, BZC, and CNC) and provide evidence for its usage in complementary and alternative medicine.
American Psychological Association (APA)
Sun, Li-Ping& Wang, Kai& Xu, Xiang& Ge, Miaomiao& Chen, Yi-Fan& Hu, Fuliang. 2017. Potential Protective Effects of Bioactive Constituents from Chinese Propolis against Acute Oxidative Stress Induced by Hydrogen Peroxide in Cardiac H9c2 Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1154434
Modern Language Association (MLA)
Sun, Li-Ping…[et al.]. Potential Protective Effects of Bioactive Constituents from Chinese Propolis against Acute Oxidative Stress Induced by Hydrogen Peroxide in Cardiac H9c2 Cells. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1154434
American Medical Association (AMA)
Sun, Li-Ping& Wang, Kai& Xu, Xiang& Ge, Miaomiao& Chen, Yi-Fan& Hu, Fuliang. Potential Protective Effects of Bioactive Constituents from Chinese Propolis against Acute Oxidative Stress Induced by Hydrogen Peroxide in Cardiac H9c2 Cells. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1154434
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154434