Analgesic and Anti-Inflammatory Effects of 80% Methanol Extract of Leonotis ocymifolia (Burm.f.) Iwarsson Leaves in Rodent Models
المؤلفون المشاركون
Tadesse, Wondmagegn Tamiru
Alemu, Asnakech
Nedi, Teshome
Shibeshi, Workineh
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-20
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Pain and inflammation are the major health problems commonly treated with traditional remedies mainly using medicinal plants.
Leonotis ocymifolia is one of such medicinal plants used in folkloric medicine of Ethiopia.
However, the plant has not been scientifically evaluated.
The aim of this study was to evaluate analgesic and anti-inflammatory effects of the 80% methanol leaves extract of Leonotis ocymifolia using rodent models.
Method.
The central and peripheral analgesic effect of the extract at 100, 200, and 400 mg/kg dose levels was evaluated using hot plate and acetic acid induced writhing rodent models, whereas carrageenan induced paw edema and cotton pellet granuloma methods were used to screen anti-inflammatory effect of the extract at the same dose levels.
Acute toxicity test was also done.
Data were analyzed using one-way ANOVA followed by Tukey’s post hoc test and p < 0.05 was considered significant.
Results.
The extract did not produce mortality up to 2000 mg/kg.
All tested doses of the extract showed significant analgesic effect with maximum latency response of 62.8% and inhibition of acetic acid induced writhing.
Maximum anti-inflammatory effect was recorded at 6 h after induction, with 75.88% reduction in carrageenan induced paw edema.
Moreover, all tested doses of extract significantly inhibited the formation of inflammatory exudates and granuloma formation ( p < 0.001 ).
Conclusion.
The study indicated that the extract was safe in mice and it has both analgesic and anti-inflammatory effect in rodent models.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Alemu, Asnakech& Tadesse, Wondmagegn Tamiru& Nedi, Teshome& Shibeshi, Workineh. 2018. Analgesic and Anti-Inflammatory Effects of 80% Methanol Extract of Leonotis ocymifolia (Burm.f.) Iwarsson Leaves in Rodent Models. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1154437
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Alemu, Asnakech…[et al.]. Analgesic and Anti-Inflammatory Effects of 80% Methanol Extract of Leonotis ocymifolia (Burm.f.) Iwarsson Leaves in Rodent Models. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1154437
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Alemu, Asnakech& Tadesse, Wondmagegn Tamiru& Nedi, Teshome& Shibeshi, Workineh. Analgesic and Anti-Inflammatory Effects of 80% Methanol Extract of Leonotis ocymifolia (Burm.f.) Iwarsson Leaves in Rodent Models. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1154437
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154437
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر