Analgesic and Anti-Inflammatory Effects of 80% Methanol Extract of Leonotis ocymifolia (Burm.f.) Iwarsson Leaves in Rodent Models
Joint Authors
Tadesse, Wondmagegn Tamiru
Alemu, Asnakech
Nedi, Teshome
Shibeshi, Workineh
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Pain and inflammation are the major health problems commonly treated with traditional remedies mainly using medicinal plants.
Leonotis ocymifolia is one of such medicinal plants used in folkloric medicine of Ethiopia.
However, the plant has not been scientifically evaluated.
The aim of this study was to evaluate analgesic and anti-inflammatory effects of the 80% methanol leaves extract of Leonotis ocymifolia using rodent models.
Method.
The central and peripheral analgesic effect of the extract at 100, 200, and 400 mg/kg dose levels was evaluated using hot plate and acetic acid induced writhing rodent models, whereas carrageenan induced paw edema and cotton pellet granuloma methods were used to screen anti-inflammatory effect of the extract at the same dose levels.
Acute toxicity test was also done.
Data were analyzed using one-way ANOVA followed by Tukey’s post hoc test and p < 0.05 was considered significant.
Results.
The extract did not produce mortality up to 2000 mg/kg.
All tested doses of the extract showed significant analgesic effect with maximum latency response of 62.8% and inhibition of acetic acid induced writhing.
Maximum anti-inflammatory effect was recorded at 6 h after induction, with 75.88% reduction in carrageenan induced paw edema.
Moreover, all tested doses of extract significantly inhibited the formation of inflammatory exudates and granuloma formation ( p < 0.001 ).
Conclusion.
The study indicated that the extract was safe in mice and it has both analgesic and anti-inflammatory effect in rodent models.
American Psychological Association (APA)
Alemu, Asnakech& Tadesse, Wondmagegn Tamiru& Nedi, Teshome& Shibeshi, Workineh. 2018. Analgesic and Anti-Inflammatory Effects of 80% Methanol Extract of Leonotis ocymifolia (Burm.f.) Iwarsson Leaves in Rodent Models. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1154437
Modern Language Association (MLA)
Alemu, Asnakech…[et al.]. Analgesic and Anti-Inflammatory Effects of 80% Methanol Extract of Leonotis ocymifolia (Burm.f.) Iwarsson Leaves in Rodent Models. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1154437
American Medical Association (AMA)
Alemu, Asnakech& Tadesse, Wondmagegn Tamiru& Nedi, Teshome& Shibeshi, Workineh. Analgesic and Anti-Inflammatory Effects of 80% Methanol Extract of Leonotis ocymifolia (Burm.f.) Iwarsson Leaves in Rodent Models. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1154437
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154437