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Bark Extracts of Ceylon Cinnamon Possess Antilipidemic Activities and Bind Bile Acids In Vitro
المؤلفون المشاركون
Ratnasooriya, W. D.
Abeysekera, Walimuni Prabhashini Kaushalya Mendis
Arachchige, Sirimal Premakumara Galbada
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-07-20
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Ethanol (95%) and dichloromethane : methanol (1 : 1) bark extracts of authenticated Ceylon cinnamon were investigated for range of antilipidemic activities (ALA): HMG-CoA reductase, lipase, cholesterol esterase, and cholesterol micellization inhibitory activities and bile acids binding in vitro.
Individual compounds in bark extracts were also evaluated.
Bark extracts showed ALA in all the assays studied.
The IC50 (μg/mL) values ranged within 153.07±8.38–277.13±32.18, 297.57±11.78–301.09±4.05, 30.61±0.79–34.05±0.41, and 231.96±9.22–478.89±9.27, respectively, for HMG-CoA reductase, lipase, cholesterol esterase, and cholesterol micellization inhibitory activities.
The bile acids binding (3 mg/mL) for taurocholate, glycodeoxycholate, and chenodeoxycholate ranged within 19.74±0.31–20.22±0.31, 21.97±2.21–26.97±1.61, and 16.11±1.42–19.11±1.52%, respectively.
The observed ALA were moderate compared to the reference drugs studied.
Individual compounds in bark extracts ranged within 2.14±0.28–101.91±3.61 and 0.42±0.03–49.12±1.89 mg/g of extract.
Cinnamaldehyde and gallic acid were the highest and the lowest among the tested compounds.
The ethanol extract had highest quantity of individual compounds and ALA investigated.
Properties observed indicate usefulness of Ceylon cinnamon bark in managing hyperlipidemia and obesity worldwide.
Further, this study provides scientific evidence for the traditional claim that Ceylon cinnamon has antilipidemic activities.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abeysekera, Walimuni Prabhashini Kaushalya Mendis& Arachchige, Sirimal Premakumara Galbada& Ratnasooriya, W. D.. 2017. Bark Extracts of Ceylon Cinnamon Possess Antilipidemic Activities and Bind Bile Acids In Vitro. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1154515
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abeysekera, Walimuni Prabhashini Kaushalya Mendis…[et al.]. Bark Extracts of Ceylon Cinnamon Possess Antilipidemic Activities and Bind Bile Acids In Vitro. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1154515
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abeysekera, Walimuni Prabhashini Kaushalya Mendis& Arachchige, Sirimal Premakumara Galbada& Ratnasooriya, W. D.. Bark Extracts of Ceylon Cinnamon Possess Antilipidemic Activities and Bind Bile Acids In Vitro. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1154515
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154515
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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