Bark Extracts of Ceylon Cinnamon Possess Antilipidemic Activities and Bind Bile Acids In Vitro
Joint Authors
Ratnasooriya, W. D.
Abeysekera, Walimuni Prabhashini Kaushalya Mendis
Arachchige, Sirimal Premakumara Galbada
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Ethanol (95%) and dichloromethane : methanol (1 : 1) bark extracts of authenticated Ceylon cinnamon were investigated for range of antilipidemic activities (ALA): HMG-CoA reductase, lipase, cholesterol esterase, and cholesterol micellization inhibitory activities and bile acids binding in vitro.
Individual compounds in bark extracts were also evaluated.
Bark extracts showed ALA in all the assays studied.
The IC50 (μg/mL) values ranged within 153.07±8.38–277.13±32.18, 297.57±11.78–301.09±4.05, 30.61±0.79–34.05±0.41, and 231.96±9.22–478.89±9.27, respectively, for HMG-CoA reductase, lipase, cholesterol esterase, and cholesterol micellization inhibitory activities.
The bile acids binding (3 mg/mL) for taurocholate, glycodeoxycholate, and chenodeoxycholate ranged within 19.74±0.31–20.22±0.31, 21.97±2.21–26.97±1.61, and 16.11±1.42–19.11±1.52%, respectively.
The observed ALA were moderate compared to the reference drugs studied.
Individual compounds in bark extracts ranged within 2.14±0.28–101.91±3.61 and 0.42±0.03–49.12±1.89 mg/g of extract.
Cinnamaldehyde and gallic acid were the highest and the lowest among the tested compounds.
The ethanol extract had highest quantity of individual compounds and ALA investigated.
Properties observed indicate usefulness of Ceylon cinnamon bark in managing hyperlipidemia and obesity worldwide.
Further, this study provides scientific evidence for the traditional claim that Ceylon cinnamon has antilipidemic activities.
American Psychological Association (APA)
Abeysekera, Walimuni Prabhashini Kaushalya Mendis& Arachchige, Sirimal Premakumara Galbada& Ratnasooriya, W. D.. 2017. Bark Extracts of Ceylon Cinnamon Possess Antilipidemic Activities and Bind Bile Acids In Vitro. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1154515
Modern Language Association (MLA)
Abeysekera, Walimuni Prabhashini Kaushalya Mendis…[et al.]. Bark Extracts of Ceylon Cinnamon Possess Antilipidemic Activities and Bind Bile Acids In Vitro. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1154515
American Medical Association (AMA)
Abeysekera, Walimuni Prabhashini Kaushalya Mendis& Arachchige, Sirimal Premakumara Galbada& Ratnasooriya, W. D.. Bark Extracts of Ceylon Cinnamon Possess Antilipidemic Activities and Bind Bile Acids In Vitro. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1154515
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154515