Effects of Qi-Fang-Xi-Bi-Granules on Cartilage Morphology and Cebpα Promoter Methylation in Rats with Knee Osteoarthritis
المؤلفون المشاركون
Qiu, HongFu
Xu, Hao
Wang, Xinxin
Shen, Peng
Wu, Tao
Gao, Xiang
Tang, De-Zhi
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-01-28
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Objective.
To investigate the effects of Qi-Fang-Xi-Bi-Granules (QFXBGs) on cartilage morphology and methylation of C/ebpα (CCAAT/enhancer binding proteinα) at the promoter region.
Methods.
Knee osteoarthritis (KOA) modeling was performed in rats in accordance with Hulth’s method, and control group received sham operation.
Eight weeks after KOA modeling, the rats in the KOA modeling group were further divided into 6 groups.
Each group was given the appropriate drug.
After 8 weeks, half of the rats were used for Micro-CT scan, HE staining, ABH/OG staining, immunohistochemistry, and TUNNEL staining of the knee joint tissue, and the other half were used to examine C/ebpα promoter methylation.
Results.
The three dose groups of QFXBGs all showed lower degrees of surface fissures and flaking, thicker cartilage layer, and restored chondrocyte and subchondral bone morphology, compared with the KOA model group.
C/ebpα-22 promoter methylation levels in the high- and low-dose groups were significantly higher than that in the KOA modeling group (p<0.05), while C/ebpα-2 promoter methylation level in the medium-dose group was significantly higher than that in the KOA modeling group (p<0.05).
Conclusions.
QFXBGs may alleviate articular cartilage degeneration through promoting C/ebpα-2 or C/ebpα-22 methylation at specific promoter sites.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Xinxin& Shen, Peng& Tang, De-Zhi& Xu, Hao& Qiu, HongFu& Wu, Tao…[et al.]. 2018. Effects of Qi-Fang-Xi-Bi-Granules on Cartilage Morphology and Cebpα Promoter Methylation in Rats with Knee Osteoarthritis. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1154532
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Xinxin…[et al.]. Effects of Qi-Fang-Xi-Bi-Granules on Cartilage Morphology and Cebpα Promoter Methylation in Rats with Knee Osteoarthritis. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1154532
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Xinxin& Shen, Peng& Tang, De-Zhi& Xu, Hao& Qiu, HongFu& Wu, Tao…[et al.]. Effects of Qi-Fang-Xi-Bi-Granules on Cartilage Morphology and Cebpα Promoter Methylation in Rats with Knee Osteoarthritis. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1154532
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154532
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر