A Chinese Herbal Formula, Gengnianchun, Ameliorates β-Amyloid Peptide Toxicity in a Caenorhabditis elegans Model of Alzheimer’s Disease
المؤلفون المشاركون
Meng, Fanhui
Li, Jun
Rao, Yanqiu
Wang, Wenjun
Fu, Yan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-11
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Alzheimer’s disease (AD) is an age-related neurodegenerative disorder, and the few drugs that are currently available only treat the symptoms.
Traditional medicine or phytotherapy has been shown to protect against AD.
In our previous studies, Gengnianchun (GNC), a traditional Chinese medicine formula with a prolongevity effect, protected against Aβ-induced cytotoxicity in pheochromocytoma cells (PC-12 cells) and hippocampal cells.
Here, we investigated the effects and possible mechanisms by which GNC protected against Aβ toxicity using transgenic Caenorhabditis elegans CL4176.
Our results showed that GNC effectively delayed the Aβ toxicity-triggered body paralysis of CL4176 worms.
GNC decreased Aβ by reducing Aβ mRNA levels.
Moreover, GNC significantly reduced reactive oxygen species in the AD model worms compared with the controls.
In addition, GNC upregulated the daf-16, sod-3, hsp-16.2 genes, and enhanced DAF-16 translocation from the cytoplasm to the nuclei under oxidative stress conditions.
GNC treatment of C.
elegans strains lacking DAF-16 did not affect the paralysis phenotype.
Taken together, these findings suggest that GNC could protect against Aβ-induced toxicity via the DAF-16 pathway in C.
elegans.
Further studies are required to analyze its effectiveness in more complex animals.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Meng, Fanhui& Li, Jun& Rao, Yanqiu& Wang, Wenjun& Fu, Yan. 2017. A Chinese Herbal Formula, Gengnianchun, Ameliorates β-Amyloid Peptide Toxicity in a Caenorhabditis elegans Model of Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1154554
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Meng, Fanhui…[et al.]. A Chinese Herbal Formula, Gengnianchun, Ameliorates β-Amyloid Peptide Toxicity in a Caenorhabditis elegans Model of Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1154554
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Meng, Fanhui& Li, Jun& Rao, Yanqiu& Wang, Wenjun& Fu, Yan. A Chinese Herbal Formula, Gengnianchun, Ameliorates β-Amyloid Peptide Toxicity in a Caenorhabditis elegans Model of Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1154554
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154554
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر