A Chinese Herbal Formula, Gengnianchun, Ameliorates β-Amyloid Peptide Toxicity in a Caenorhabditis elegans Model of Alzheimer’s Disease
Joint Authors
Meng, Fanhui
Li, Jun
Rao, Yanqiu
Wang, Wenjun
Fu, Yan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Alzheimer’s disease (AD) is an age-related neurodegenerative disorder, and the few drugs that are currently available only treat the symptoms.
Traditional medicine or phytotherapy has been shown to protect against AD.
In our previous studies, Gengnianchun (GNC), a traditional Chinese medicine formula with a prolongevity effect, protected against Aβ-induced cytotoxicity in pheochromocytoma cells (PC-12 cells) and hippocampal cells.
Here, we investigated the effects and possible mechanisms by which GNC protected against Aβ toxicity using transgenic Caenorhabditis elegans CL4176.
Our results showed that GNC effectively delayed the Aβ toxicity-triggered body paralysis of CL4176 worms.
GNC decreased Aβ by reducing Aβ mRNA levels.
Moreover, GNC significantly reduced reactive oxygen species in the AD model worms compared with the controls.
In addition, GNC upregulated the daf-16, sod-3, hsp-16.2 genes, and enhanced DAF-16 translocation from the cytoplasm to the nuclei under oxidative stress conditions.
GNC treatment of C.
elegans strains lacking DAF-16 did not affect the paralysis phenotype.
Taken together, these findings suggest that GNC could protect against Aβ-induced toxicity via the DAF-16 pathway in C.
elegans.
Further studies are required to analyze its effectiveness in more complex animals.
American Psychological Association (APA)
Meng, Fanhui& Li, Jun& Rao, Yanqiu& Wang, Wenjun& Fu, Yan. 2017. A Chinese Herbal Formula, Gengnianchun, Ameliorates β-Amyloid Peptide Toxicity in a Caenorhabditis elegans Model of Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1154554
Modern Language Association (MLA)
Meng, Fanhui…[et al.]. A Chinese Herbal Formula, Gengnianchun, Ameliorates β-Amyloid Peptide Toxicity in a Caenorhabditis elegans Model of Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1154554
American Medical Association (AMA)
Meng, Fanhui& Li, Jun& Rao, Yanqiu& Wang, Wenjun& Fu, Yan. A Chinese Herbal Formula, Gengnianchun, Ameliorates β-Amyloid Peptide Toxicity in a Caenorhabditis elegans Model of Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1154554
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154554