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Establishment and Validation of an In Vitro Screening Method for Traditional Chinese Medicine-Induced Nephrotoxicity
المؤلفون المشاركون
Zhu, Yan
Wang, Meng
Dong, Ran-Ran
Ma, Zhe
Cao, Xuexiao
Guo, Xiao
Ren, Xiaoliang
Shao, Rui
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-28
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Renal injury is among the adverse drug reactions (ADRs) caused by herbal medicine products (HMPs).
Traditional Chinese medicines (TCMs) have been practiced for over 2000 years in China and East Asia, and herbs are currently used worldwide for the treatment and prevention of chronic and acute disease.
Operetta high content analysis (HCA, PerkinElmer, Waltham, MA, USA), which is an in vitro, sensitive, reproducible, multiparametric screening method, was used to evaluate the cytotoxicity of HMPs in cultures of HEK293 human embryo kidney cells.
Cytotoxic results were validated by an animal-based subacute toxicity assay.
The renal safety of 18 active pharmaceutical agents from 13 TCM herbs with known nephrotoxic potential was evaluated in HEK293 human embryonic kidney cells.
A panel of five parameters, cell viability, nuclear area, nuclear roundness, mitochondrial mass, and mitochondrial membrane potential, was utilized to evaluate drug-induced renal mitochondrial and nuclear injury.
HCA can be a useful tool for preclinical screening and postclinical evaluation of HMPs.
The nephrotoxicity of diosbulbin B and other HMPs was evident at a concentration as low as 0.01 μM.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ma, Zhe& Cao, Xuexiao& Guo, Xiao& Wang, Meng& Ren, Xiaoliang& Dong, Ran-Ran…[et al.]. 2018. Establishment and Validation of an In Vitro Screening Method for Traditional Chinese Medicine-Induced Nephrotoxicity. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1154600
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ma, Zhe…[et al.]. Establishment and Validation of an In Vitro Screening Method for Traditional Chinese Medicine-Induced Nephrotoxicity. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1154600
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ma, Zhe& Cao, Xuexiao& Guo, Xiao& Wang, Meng& Ren, Xiaoliang& Dong, Ran-Ran…[et al.]. Establishment and Validation of an In Vitro Screening Method for Traditional Chinese Medicine-Induced Nephrotoxicity. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1154600
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154600
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