Lannea acida A. Rich. (Anacardiaceae) Ethanol Extract Exhibits Estrogenic Effects and Prevents Bone Loss in an Ovariectomized Rat Model of Osteoporosis
المؤلفون المشاركون
Zingue, Stephane
Njamen, Dieudonné
Oumarou, Mouchili Riepouo
Bakam, Berlise Yengwa
Ateba, Sylvin Benjamin
Mbakop, Fritz Teddy Tchaptchet
Foyet, Harquin Simplice
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-11-27
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Phytoestrogens have been shown to prevent postmenopausal osteoporosis.
Lannea acida is a medicinal plant traditionally used in Cameroon to treat infertility, gynaecological complaints, and rheumatism.
These uses prompted us to evaluate estrogenic activity of Lannea acida bark ethanolic extract and its antiosteoporotic potential in ovariectomized Wistar rats.
In vitro, the E-screen assay was used to assess the ability of L.
acida extract to induce MCF-7 cells proliferation.
In vivo, a 3-day uterotrophic assay and a 12-week oral treatment in ovariectomized adult rats were carried out to evaluate the ability of L.
acida extract to prevent bone mass loss.
L.
acida extract induced MCF-7 cell proliferation.
In vivo, it significantly increased the uterine wet weight, uterine and vaginal epithelial heights, and mammary glands differentiation.
At 200 mg/kg, a long-term treatment with the extract prevented body weight gain (p<0.05) and loss of bone mass and/or density (p<0.05) induced by ovariectomy.
Also, a significant (p<0.001) decrease of alkaline phosphatase activity was observed with 50 mg/kg.
L.
acida extract improved bone microarchitecture and could restore normal bone mineralization by increasing the inorganic phosphorus and calcium level in bone.
These findings provide evidence that Lannea acida is a potential alternative for the prevention of postmenopausal osteoporosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Oumarou, Mouchili Riepouo& Zingue, Stephane& Bakam, Berlise Yengwa& Ateba, Sylvin Benjamin& Foyet, Harquin Simplice& Mbakop, Fritz Teddy Tchaptchet…[et al.]. 2017. Lannea acida A. Rich. (Anacardiaceae) Ethanol Extract Exhibits Estrogenic Effects and Prevents Bone Loss in an Ovariectomized Rat Model of Osteoporosis. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1154608
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Oumarou, Mouchili Riepouo…[et al.]. Lannea acida A. Rich. (Anacardiaceae) Ethanol Extract Exhibits Estrogenic Effects and Prevents Bone Loss in an Ovariectomized Rat Model of Osteoporosis. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1154608
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Oumarou, Mouchili Riepouo& Zingue, Stephane& Bakam, Berlise Yengwa& Ateba, Sylvin Benjamin& Foyet, Harquin Simplice& Mbakop, Fritz Teddy Tchaptchet…[et al.]. Lannea acida A. Rich. (Anacardiaceae) Ethanol Extract Exhibits Estrogenic Effects and Prevents Bone Loss in an Ovariectomized Rat Model of Osteoporosis. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1154608
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154608
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر