Lannea acida A. Rich. (Anacardiaceae) Ethanol Extract Exhibits Estrogenic Effects and Prevents Bone Loss in an Ovariectomized Rat Model of Osteoporosis
Joint Authors
Zingue, Stephane
Njamen, Dieudonné
Oumarou, Mouchili Riepouo
Bakam, Berlise Yengwa
Ateba, Sylvin Benjamin
Mbakop, Fritz Teddy Tchaptchet
Foyet, Harquin Simplice
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-27
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Phytoestrogens have been shown to prevent postmenopausal osteoporosis.
Lannea acida is a medicinal plant traditionally used in Cameroon to treat infertility, gynaecological complaints, and rheumatism.
These uses prompted us to evaluate estrogenic activity of Lannea acida bark ethanolic extract and its antiosteoporotic potential in ovariectomized Wistar rats.
In vitro, the E-screen assay was used to assess the ability of L.
acida extract to induce MCF-7 cells proliferation.
In vivo, a 3-day uterotrophic assay and a 12-week oral treatment in ovariectomized adult rats were carried out to evaluate the ability of L.
acida extract to prevent bone mass loss.
L.
acida extract induced MCF-7 cell proliferation.
In vivo, it significantly increased the uterine wet weight, uterine and vaginal epithelial heights, and mammary glands differentiation.
At 200 mg/kg, a long-term treatment with the extract prevented body weight gain (p<0.05) and loss of bone mass and/or density (p<0.05) induced by ovariectomy.
Also, a significant (p<0.001) decrease of alkaline phosphatase activity was observed with 50 mg/kg.
L.
acida extract improved bone microarchitecture and could restore normal bone mineralization by increasing the inorganic phosphorus and calcium level in bone.
These findings provide evidence that Lannea acida is a potential alternative for the prevention of postmenopausal osteoporosis.
American Psychological Association (APA)
Oumarou, Mouchili Riepouo& Zingue, Stephane& Bakam, Berlise Yengwa& Ateba, Sylvin Benjamin& Foyet, Harquin Simplice& Mbakop, Fritz Teddy Tchaptchet…[et al.]. 2017. Lannea acida A. Rich. (Anacardiaceae) Ethanol Extract Exhibits Estrogenic Effects and Prevents Bone Loss in an Ovariectomized Rat Model of Osteoporosis. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1154608
Modern Language Association (MLA)
Oumarou, Mouchili Riepouo…[et al.]. Lannea acida A. Rich. (Anacardiaceae) Ethanol Extract Exhibits Estrogenic Effects and Prevents Bone Loss in an Ovariectomized Rat Model of Osteoporosis. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1154608
American Medical Association (AMA)
Oumarou, Mouchili Riepouo& Zingue, Stephane& Bakam, Berlise Yengwa& Ateba, Sylvin Benjamin& Foyet, Harquin Simplice& Mbakop, Fritz Teddy Tchaptchet…[et al.]. Lannea acida A. Rich. (Anacardiaceae) Ethanol Extract Exhibits Estrogenic Effects and Prevents Bone Loss in an Ovariectomized Rat Model of Osteoporosis. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1154608
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154608