Antiasthmatic Effects of Sanglong Pingchuan Decoction through Inducing a Balanced Th1Th2 Immune Response
المؤلفون المشاركون
Zhu, Binnian
Dong, Jun
Gao, Xiangyun
He, Yanfei
Sun, Hongxiang
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-11
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Objective.
To investigate the antiasthmatic effects of Sanglong pingchuan decoction (SLPCD) and to explore its mechanisms of action.
Methods.
The serum, bronchoalveolar lavage fluid (BALF), and lung tissues from OVA-induced allergic asthma mice were collected 24 h after the last administration.
Lung pathological changes were observed by H&E staining.
The inflammatory cells in BALF were counted by flow cytometry.
The levels of total IgE in serum and cytokines in BALF were determined by ELISA.
The expression levels of cytokine mRNA in lung were assayed by qRT-PCR.
Results.
SLPCD significantly inhibited airway inflammation, reduced inflammatory cells in BALF, reduced the levels of total IgE in serum and Th2 cytokines (IL-10 and IL-13) in BALF, and downregulated the mRNA expression levels of Th2 cytokines (IL-4, IL-5, IL-10, and IL-13) in lung of asthmatic mice.
However, SLPCD remarkably elevated the level of Th1 cytokine IFN-γ in BALF and upregulated the mRNA expression levels of Th1 cytokines (IL-2 and IFN-γ) in lung of asthmatic mice.
Conclusion.
SLPCD could attenuate airway inflammation and alleviate the pathogenesis in asthma mice through inducing a balanced Th1/Th2 response and could act as an effective drug for treatment of asthma.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhu, Binnian& Dong, Jun& Gao, Xiangyun& He, Yanfei& Sun, Hongxiang. 2018. Antiasthmatic Effects of Sanglong Pingchuan Decoction through Inducing a Balanced Th1Th2 Immune Response. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1154642
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhu, Binnian…[et al.]. Antiasthmatic Effects of Sanglong Pingchuan Decoction through Inducing a Balanced Th1Th2 Immune Response. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1154642
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhu, Binnian& Dong, Jun& Gao, Xiangyun& He, Yanfei& Sun, Hongxiang. Antiasthmatic Effects of Sanglong Pingchuan Decoction through Inducing a Balanced Th1Th2 Immune Response. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1154642
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154642
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر